微小RNA与卵巢癌铂类耐药的研究进展

微小RNA(micmRNA,miBNA)是广泛存在于生物体内的一类非编码的小RNA,miRNA是细胞增殖、死亡、应激抗性和脂肪代谢的关键调节因素,体外实验已经证实miRNA在卵巢癌耐药中起重要作用.卵巢癌铂类耐药的产生与发展是十分复杂的过程,研究结果显示,miRNA的表达对卵巢癌细胞株的铂类药物敏感性有着重要作用,能够...

MicroRNA in platinum-resistance of ovarian cancer

MircoRNAs (miRNAs) are widely existing inorganisms, non-coding small RNA. MircoR-NAs play important role in cell proliferation, apoptosis, stress resistance and fat metabolism. In vitro studies indicate that miRNAs are important factors in platinum resistance of ovarian cancer cell lines. However, the pathway of platinum resistance of ovarian cancers is complex. Studies find miRNA expression play important roles in the sensitivity of platinum resistance of ovarian cancer cell lines , and can be used as an early alert for platinum resistance. Changing the expression of miRNA even can reverse the platinum resistance . But the regular role of miRNAs in target genes network is still unconfirmed. Thus, more studies about miRNA in vivo and animal tumor models are needed to identify the function of miRNAs in platinum resistance of ovarian cancer.