小儿单纯性肥胖症胰腺内分泌功能研究

目的:探讨单纯性肥胖(SO)患儿胰腺内分泌功能。方法:采用放射免疫分析法测定SO患儿空腹和摄入液体实验餐60 min时外周血胰岛素、胰高血糖素和生长抑素(SS)水平。结果:与对照组比较,SO患儿空腹时血中胰岛素、胰高血糖素明显升高(P<0.01),而SS水平无明显差异(P>0.05),其餐后血中胰岛素、胰高血糖素也明显升高(P<0.01),而SS水平则明显降低(P<0.01);空腹与餐后比较,SO患儿餐后血中胰岛素水平明显升高(P<0.01),胰高血糖素及SS水平无明显变化(P>0.05),对照组则血中胰岛素和SS水平升高(P<0.01),胰高血糖素水平无明显变化(P>0.05)。结论:SO患儿存在明显的胰腺内分泌功能紊乱,应引起高度重视。

Study on function of pancreatic endrine in simple obesity in children

Objective:To reveal the function of pancreatic endocrine in simple obesity in children.Methods:The blood levels of insulin,glucagon and somatostatin before and on 60 minutes after ingestion of test meal were measured by radioimmunassay in 40 children with OB and 30 age-sex matched healthy children as controls.Results:The preprandial levels of insulin and glucagon were higher(P<0.01),however,the preprandial level of somatostatin was no significant difference(P>0.05) in OB group than those of control group.The postprandial levels of insulin and glucagon were higher too(P<0.01),however,the level of somatostatin was lower in OB group than those of control group(P<0.01).In comparison with the preprandial levels,the postprandial level of insulin was higher(P<0.01),however,the postprandial levels of glucagon and somatostatin were no significant difference(P>0.05) in OB group,but in control group,the postprandial levels of insulin and somatostatin were higher(P<0.01) and glucagon was no significant difference(P>0.05).Conclusion:The function of pancreatic endocrines is disorder in children with OB.