多巴胺D2受体基因的TaqI A多态性与迟发性运动障碍的关联分析

目的　研究多巴胺D2受体 (DRD2 )基因TaqIA多态性与精神分裂症伴迟发性运动障碍 (TD)的相关性。方法　使用异常不自主运动量表 (AIMS)评定精神分裂症患者有无TD及TD严重程度 ,并采用简明精神病评定量表 (BPRS)评定患者精神症状 ;应用聚合酶链反应 (PCR)—限制性片段长度多态性 (RFLP)法分析TD组和非TD组的DRD2基因的TaqIA等位基因频率和基因型分布。结果　DRD2基因TaqIA的等位基因频率和基因型分布在TD组与非TD组之间均无显著性差异 ,且不同基因型间的AIMS总分值也无显著性差异。结论　在中国汉族男性精神分裂症患者中DRD2基因的TaqIA多态性可能不是影响TD发生的主要危险因素。

Association of TaqI A polymorphism of dopamine D2 receptor gene and tardive dyskinesia in schizophrenia

Objective To investigate the association of TaqI A polymorphism of dopamine D2 receptor (DRD2) gene with tardive dyskinesia (TD) in Chinese Han males with schizophrenia. Methods The polymorphism of the DRD2 gene was examined using polymerase chain reaction (PCR) which was based on restriction fragment length polymorphism (RFLP) analysis. Diagnosis of the presence and severity of TD were assessed by the Abnormal Involuntary Movement Scale (AIMS). Psychiatric symptoms were also rated using the Brief Psychiatric Rating Scale (BPRS). Results There were no significant differences in the distributions of the allelic frequencies and genotypes of TaqI A polymorphism of DRD2 gene between the groups (P>0.05). Genotypes of DRD2 gene were not correlated with total AIMS scores in TD patients (P>0.05). Conclusions Our results suggested that the TaqI A polymorphism of DRD2 gene may not be a major risk factor for the development of TD in male Chinese Han schizophrenia.