Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro |
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Authors: | THOMAS MODÉ ER,GÖ RAN DAHLLÖ F,JOHAN KARSTEN,PER OTTESKOG |
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Affiliation: | Department of Pedodontics, Odontological Faculty, Karolinska Institute, Huddinge, Sweden |
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Abstract: | Abstract – Human mononuclear cells purified by Lymphoprep flotation were incubated with phenytoin (PHT) (20 μg/ml) or its metabolite p-HPPH (2 μg/ml) in the presence of Concanaval-in A (10 μg/ml) in vitro. The results indicate that phenytoin and its metabolite p-HPPH induce the release of a mononuclear cell factor(s) that activates quiescent human gingival fibroblast to synthesize DNA. |
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Keywords: | cell proliferation fibroblast mononuclear cells phenytoin |
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