帕罗西汀治疗伴情绪障碍的偏头痛

目的：探讨帕罗西汀治疗伴有情绪障碍的偏头痛的临床疗效。方法：将偏头痛病人127例分为2组,帕罗西汀组68例[男性26例,女性42例,年龄(30±s 12)a,13～74 a],口服帕罗西汀20 mg,每早1次,1 wk后加至40 mg,每早1次,头痛缓解1wk后给予维持量10mg,每早1次；硫必利组59例[男性24例,女性35例,年龄(30±18)a,15～68 a],入院后即给予硫必利100mg,每日3次,维持量为50 mg,每日2～3次,均6wk为一个疗程。进行对照研究,用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)对其抑郁焦虑状态进行治疗前及治疗后(wk 2,4,6)评估。结果：帕罗西汀组和硫必利组不仅可以明显减轻病人的抑郁焦虑症状,还可以显著减轻偏头痛发作次数,缩短头痛发作的时间(P＜0．01)；帕罗西汀组总有效率96%(65/68),硫必利组总有效率81%(48/59),2组疗效比较,经Ridit分析有显著差异(P＜0．05)。结论：帕罗西汀治疗伴有情绪障碍的偏头痛有较好疗效。

Paroxetine in treatment of migraine with emotional disorder

AIM:To study the clinic efficacy of paroxetine in curing migraine with emotional disorder. METHODS:One hundred and twenty-seven patients were divided into 2 groups.The paroxetine group(n=68, M26,F42;age(30±s12)a,13-74a)were treated with paroxetine 20mg,po,qd,then added to 40mg, po,qd,one week later and then until one week after relief of headache reducing dose to 10mg,po,qd as for maintenance.The tiapride group(n=59,M24,F35;age(30±18)a,15-68a)were treated with tiapride 100mg,po,tid,and with maintaining dose of 50mg,po,bid or tid.The whole course all covered for 6 wk. The depression and anxiety status were evaluated with HAMD depression capacity table and HAMA anxiety capac- ity table.RESULTS:Paroxetine could not only decrease the depression and anxiety symptoms in patients obvi- ously but also reduce the attack times of headache and shorten the attack time of headache remarkably in paroxe- tine group(P＜0.05,P＜0.01).The efficacy rate of paroxetine group reached 96%(65/68),and that of tiapride group was 81%(48/59),with P＜0.05 by Ridit analysis.CONCLUSION:Paroxetine possesses better ef- ficacy in curing migraine.