| 哺乳动物生殖细胞的形成、性分化和永生化 |
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| 引用本文： | 刘善荣,胡凯猛,刘厚奇,戚中田. 哺乳动物生殖细胞的形成、性分化和永生化[J]. 第二军医大学学报, 2003, 24(9): 960-962 |
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| 作者姓名： | 刘善荣 胡凯猛 刘厚奇 戚中田 |
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| 作者单位： | 1. 第二军医大学基础医学部组织胚胎学教研室,上海,200433
2. 基础医学部微生物学教研室 |
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| 基金项目： | 国家杰出青年科学基金 ( 3 982 5 116)，海外青年学者合作研究基金 ( 3 992 80 0 9) |
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| 摘 要： | 小鼠原始生殖细胞产生于原肠胚形成阶段,迁移到生殖嵴位置后获得性别分化决定.体外培养时原始生殖细胞可大量增殖,现在已经建立了人类EG细胞株,这些永生的EG细胞具有正常的核型和多向分化能力,它可分化为某些特定的细胞类型,在临床上对退行性疾病的治疗有一定的意义.
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| 关 键 词： | 原始生殖细胞、性分化、永生化、综述文献 |
| 文章编号： | 0258-879X(2003)09-0960-03 |
| 修稿时间： | 2003-03-14 |
Birth, sex differentiation and immortalization of mammalian germ cells |
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| LIU Shan Rong ,HU Kai Meng ,LIU Hou Qi ,QI Zhong Tian. Birth, sex differentiation and immortalization of mammalian germ cells[J]. Former Academic Journal of Second Military Medical University, 2003, 24(9): 960-962 |
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| Authors: | LIU Shan Rong HU Kai Meng LIU Hou Qi QI Zhong Tian |
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| Affiliation: | LIU Shan Rong 1,HU Kai Meng 1,LIU Hou Qi 1*,QI Zhong Tian 2 |
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| Abstract: | The germ cell lineage in the mouse is established during gastrulation;sex determination is achieved after germ cell migrating to the site of the future gonads. Germ cells proliferate indefinitely when cultured in vitro . Human embryonic germ(EG) cells have been recently established;these immortalized EG cells are chromosomally stable and pluripotent, raising the hope that their differentiation can be directed to specific cell types, which may be of value in the clinical treatment of degenerative diseases. |
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| Keywords: | primordial germ cells sex differentiation immortalization review literature |
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