| MMP-9-1562C/T基因多态性与2型糖尿病肾病关系的研究 |
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| 引用本文： | 潘明麟,张晓梅,孙卫华,徐浣白,时照明,田刚.MMP-9-1562C/T基因多态性与2型糖尿病肾病关系的研究[J].天津医药,2010,38(8). |
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| 作者姓名： | 潘明麟 张晓梅 孙卫华 徐浣白 时照明 田刚 |
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| 作者单位： | 1. 蚌埠医学院第一附属医院内分泌科,233004
2. 天津市公安医院检验科 |
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| 基金项目： | 安徽省卫生厅基金资助项目 |
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| 摘 要： | 目的:探讨2型糖尿病(T2DM)患者基质金属蛋白酶-9基因-1562C/T(MMP-9-562C/T)多态性与糖尿病肾病(DN)及DN不同病期的关系.方法:将150例T2DM患者按DN诊断标准分为 DN 组与非糖尿病肾病(NDN)组,DN组分为微量白蛋白尿期、临床白蛋白尿期和肾功能不全期.另择52例健康人作为正常对照(NC)组.应用限制性片段长度多态性(RFLP)分析各组基因型.结果:DN组的糖化血红蛋白(HbA1c)、收缩压(SBP)、肌酐(Cr)、尿素氮(BUN)、尿微量白蛋白排泄率(UAER)值高于 NDN、NC组(P<0.01).DN组与NDN 组、NC组之间基因型分布差别均有统计学意义(P<0.01).T2DM中CC、CT、TT各基因型DN发生率依次递减,其中TT基因型组DN发生率低于CC基因型组(P<0.01).携 T 等位基因者发生DN的风险是携C等位基因者的0.47倍 (P<0.01,95%CI 0.29～0.75).MMP-9-1562 C基因型、HbA1c、TG、TC、Cr、BUN、SBP是DN发生的危险因素;DN组内微量白蛋白尿期、临床自蛋白尿期和肾功能不全期TT基因型与T等位基因频率随肾功能减退而降低(P<0.05或P<0.01).结论:MMP-9-1562C/T 基因多态性与DN发生有关,T等位基因是DN患者的保护基因.
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| 关 键 词： | 糖尿病 2型 糖尿病肾病 基质金属蛋白酶9 多态性 限制性片段长度 白蛋白尿 Logistic模型 |
Study on the Relationship between Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism and Diabetic Nephropathy |
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| PAN Minglin,ZHANG Xiaomei,SUN Weihua,XU Huanbai,SHI Zhaoming,TIAN Gang.Study on the Relationship between Matrix Metalloproteinase-9 Gene-1562C/T Polymorphism and Diabetic Nephropathy[J].Tianjin Medical Journal,2010,38(8). |
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| Authors: | PAN Minglin ZHANG Xiaomei SUN Weihua XU Huanbai SHI Zhaoming TIAN Gang |
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| Institution: | PAN Minglin,ZHANG Xiaomei,SUN Weihua,XU Huanbai,SHI Zhaoming,TIAN Gang Department of Endocrinology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China |
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| Abstract: | Objective: To explore the relationship between matrix metalloproteinase-9 (MMP-9) gene -1562C/T and diabetic nephropathy (DN) with different stage. Methods: One hundred and fifty patients with type 2 diabetes (T2DM) were divided into DN group and diabetes without DN (NDN) group. Patients in DN group included microamount albuminuria, clinical alubuminuria and renal inadequacy stages. Fifty-two healthy people were selected as normal control (NC) group. The genotypes were assessed by restriction fragment lengt... |
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| Keywords: | diabetes mellitus type 2 diabetic nephropathies matrix metalloproteinase 9 polymorphism restriction fragment length albuminuria Logistic models |
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