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| Bowen病bcl-2及P53蛋白的表达 | |
| 引用本文： | 张士发,王良明,赵丽萍,许静,顾绍裘.Bowen病bcl-2及P53蛋白的表达[J].中国麻风皮肤病杂志,2004,20(4):328-329. |
| 作者姓名： | 张士发 王良明 赵丽萍 许静 顾绍裘 |
| 作者单位： | 1. 沈阳军区总医院皮肤性病科,沈阳,110016 2. 中国医科大学第二临床学院皮肤科 3. 中国医科大学第一临床学院皮肤科 |
| 摘 要： | 目的 : 探讨bcl- 2及P5 3蛋白在Bowen病及Bowen样鳞癌中的表达及其意义。方法 : 应用免疫组织化学技术对 11例Bowen病及 3例Bowen样鳞癌bcl- 2和 或P5 3蛋白的表达进行了检测。结果 :11例Bowen病中bcl- 2蛋白阳性 2例 (18% ) ,P5 3蛋白阳性 3例 (2 7% ) ;3例Bowen样鳞癌均见bcl- 2蛋白表达。Bowen病中bcl- 2与P5 3蛋白表达显著正相关 (r=0 .76 9,P <0 .0 5 )。结论 : Bowen病中bcl- 2蛋白表达与P5 3基因突变有关 ,并参与了Bowen病的进展及向Bowen样鳞癌的演变 |
| 关 键 词： | Bowen病 Bowen样鳞癌 bcl-2蛋白 P53蛋白 |
| 修稿时间： | 2003年8月18日 |
Expressions of bcl-2 and P53 protein in Bowen's disease |
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| Zhang Shifa,Wang Liangming,Zhao Liping,et al..Expressions of bcl-2 and P53 protein in Bowen''''s disease[J].China Journal of Leprosy and Skin Diseases,2004,20(4):328-329. | |
| Authors: | Zhang Shifa Wang Liangming Zhao Liping |
| Affiliation: | Zhang Shifa,Wang Liangming,Zhao Liping,et al. Department of Dermatology,General Hospital of Shenyang Military Region,Shenyang,110016 |
| Abstract: | Objective: To study the expression of bcl-2 and P53 protein in Bowen's disease and bowenoid squamous cell carcinoma(BSCC) and the significance. Methods:The bcl-2 and/or P53 protein were immunohistochemically detected in 11 cases of Bowen's disase and BSCC.Results:bcl-2 protein were postitive (18%) and 3 of them were P53 protein positive (27%) in 2 of 11 cases of Bowen's disease and 3 cases of BSCC. In Bowen's disease, the expression of bcl-2 protein was significantly positively correlated to that of P53 protein (r=0.769, P<0.05). Conclusion:In Bowen's disease, the expression of bcl-2 protein was correlated to the P53 gene mutation and takes part in the disease progression and transforming to BSCC. |
| Keywords: | Bowen's desease Bowenoid squamous cell carcinoma bcl-2 protein P53 protein |
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