大肠癌组织中环氧合酶蛋白的表达

目的：研究大肠癌组织中环氧合酶1和2（COX－1和COX－2）的表达，探讨其与临床病理特征的关系。方法：采用免疫组化SP法检测COX－1和COX－2在68例大肠癌组织和10例正常大肠组织中的表达。结果：（1）COX－1在正常大肠粘膜及大肠癌组织中均有不同程度的表达，阳性率分别为100％和92．4％，差异无统计学意义（P＞0．05）。（2）COX－2在大肠癌组织中的阳性表达率为66．18％，在正常大肠粘膜中未见表达，差异有统计学意义（P＜0．05）。（3）COX－2在有淋巴结转移的大肠癌组织的表达（74．07％）明显高于其在无淋巴结转移者（35．71％），差异有统计学意义（P＜0．05）。（4）COX－2在大肠癌组织中的表达率与大肠癌的大体分型，组织学分型，肿瘤大小，肿瘤部位及患者性别，年龄均无明显关系。结论：COX－2可能与大肠癌的发生发展及淋巴转移有密切相关系，而COX－1与大肠癌的发生无关。

Expression of COX in human colorectal carcinoma tissues

Aim:To investigate the expression of COX-1 and COX-2 in eolorectal carcinoma tissues,and study its correlation with clinicopathologic characteristics. Methods: COX-1 and COX-2 expression were examined by immunohisto-ehemistry in 68 specimens of eolorectal carcinoma tissues and 10 specimens of normal eolorectal tissues. Results:The positive rates of COX-1 expression in normal mucosa and eolorectal carcinoma were 100% and 92.64% respectively and there was no significant difference between them(P >0. 05). The positive rate of COX-2 expression in eolorectal carcinoma was 66.18% (45/68) , and there was no expression in normal eolorectal mucosa. The expression of COX-2 has significant difference between eolorectal carcinoma and normal coloretal mucosa(P <0. 05) . The positive rate of COX-2 in group with lymph node metastasis was 74.07% (40/54) and 35.71% (5/14) in group without. There was significant difference between the 2 groups(P < 0. 05). The expression of COX-2 had no correlation to the cancer gross types, histologic types, size of tumor, and sex and age of patients. Conclusion: COX-2 might play an important role in the carcinogenesis and metastasis of eolorectal cancinoma,but there is no correlation between COX-1 and the carcinogenesis of eolorectal carcinoma.