| 福州市某综合性医院城镇老年患者住院费用调查与分析 |
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| 引用本文： | 吴任慰,江 琴,戴志婉.福州市某综合性医院城镇老年患者住院费用调查与分析[J].南京医科大学学报,2009,29(1):36-39. |
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| 作者姓名： | 吴任慰 江 琴 戴志婉 |
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| 作者单位： | 南京医科大学第二附属医院心内科,江苏,南京,210011
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| 基金项目： | 江苏省科技厅社会发展项目 |
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| 摘 要： | 目的:研究依达拉奉对急性脑缺血大鼠脑自由基水平变化和脑源性神经生长因子(BDNF)表达的影响,并探讨其可能机制.方法:采用线栓法制备大鼠大脑中动脉缺血-再灌注模型,分为假手术组、生理盐水对照组和依达拉奉组.每组分为6、12、24、48 h 4个亚组.检测各组脑组织不同时间点丙二醛(MDA)、过氧化物歧化酶(SOD)含量,用RT-PCR和Western-blot检测皮层BDNF mRNA和蛋白质表达变化.结果:依达拉奉干预组显著降低MDA含量(P<0.01),增加SOD活性(P<0.05),与对照组比较有统计学差异.依达拉奉组BDNF mRNA表达水平明显高于对照组,表达时相延长.BDNF蛋白表达亦较对照组明显增加.结论:依达拉奉能显著降低MDA含量,增加SOD水平,具有明显的清除自由基作用,并能显著增加缺血再灌注后脑皮层BDNF的表达,推测依达拉奉还具有清除自由基以外的脑保护作用.
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| 关 键 词： | 脑源性神经生长因子 自由基 依达拉奉 缺血再灌注 |
| 收稿时间： | 2008/10/13 0:00:00 |
Effects of Edaravone on free radicals and brain-derived neurotrophic factor after focal cerebral ischemia-reperfusion injury in rats |
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| WU Ren-Wei,JIANG Qin and DAIZhi-Wan.Effects of Edaravone on free radicals and brain-derived neurotrophic factor after focal cerebral ischemia-reperfusion injury in rats[J].Acta Universitatis Medicinalis Nanjing,2009,29(1):36-39. |
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| Authors: | WU Ren-Wei JIANG Qin and DAIZhi-Wan |
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| Institution: | Department of Cardiology;the Second Affiliated Hospital of NJMU;Nanjing 210011;China |
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| Abstract: | Objective:To study the effect of edaravone on contents of SOD,MDA and the expression of BDNF (brain-derived neu- rotrophic factor) in cerebral cortex after MCAO / R (middle cerebral artery occlusion / reperfusion) injury and its possible mechanisms in rats. Methods:A total of 72 healthy male rats were randomly divided into sham-operation group(n = 24), control group(n = 24) and edaravone treated group (n = 24). Each group was further divided into 6 h,12 h,24 h and 48 h subgroups. The levels of SOD and MDA o... |
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| Keywords: | BDNF free radical edaravone ischemia-reperfusion |
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