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| D-R聚甘酯对局灶性脑缺血大鼠的保护作用 | |
| 引用本文： | 王淑民,陈红艳,王建华,赵秀丽,管华诗. D-R聚甘酯对局灶性脑缺血大鼠的保护作用[J]. 中国临床药理学杂志, 2011, 27(2) |
| 作者姓名： | 王淑民 陈红艳 王建华 赵秀丽 管华诗 |
| 作者单位： | 1. 首都医科大学附属北京同仁医院,北京,100730 2. 中国人民解放军总医院老年医学研究所,北京,100853 3. 中国海洋大学海洋药物与食品研究所,山东,青岛,266003 |
| 基金项目： | 国家中医药管理局基金资助项目(04-05ZP09) |
| 摘 要： | 目的研究D-聚甘酯(多糖类化合物)对大鼠局灶性脑缺血再灌注损伤(RI)的保护作用及其可能机制。方法用改良Longa法,建立大鼠局灶性脑缺血2 h再灌注损伤模型,观察D-聚甘酯对脑缺血再灌注大鼠的脑组织中丙二醛(MDA)含量及对超氧化物歧化酶(SOD)、谷胱苷肽过氧化物酶(GSH-PX)活性的影响。结果模型组大鼠在RI 24 h、RI 72 h及RI 144h时,MDA含量明显高于假手术组;而SOD和GSH-PX活性降低。D-聚甘酯可降低MDA含量,升高SOD和GSH-PX活性,尤其是在RI 144 h。结论 D-聚甘酯对脑缺血再灌注损伤有保护作用,其机制可能与抗缺血性脑组织中的自由基有关。 |
| 关 键 词： | D-聚甘酯 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
Protective effects of D-polymannuronicate on focal cerebral ischemia in rats |
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| WANG Shu-min,CHEN Hong-yan,WANG Jian-hua,ZHAO Xiu-li,GUAN Hua-shi. Protective effects of D-polymannuronicate on focal cerebral ischemia in rats[J]. The Chinese Journal of Clinical Pharmacology, 2011, 27(2) | |
| Authors: | WANG Shu-min CHEN Hong-yan WANG Jian-hua ZHAO Xiu-li GUAN Hua-shi |
| Affiliation: | WANG Shu-min1,CHEN Hong-yan2,WANG Jian-hua2,ZHAO Xiu-li1,GUAN Hua-shi3(1.Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China,2.Institute of Geriatrics,General Hospital of PLA,Beijing 100853,3.Marine Drug and Food Institute,Ocean University of China,Qingdao 266003,Shandong Provine,China) |
| Abstract: | Objective To study the protective effects of D-polymannuronicate(DPS) on focal cerebral ischemia-reperfusion injury(RI) in rats and explore the mechanisms.Methods The modified Longa method was applied to establish the models of focal cerebral ischemia 2 h reperfusion injury in rats.To observe the effects of DPS on the content of malondialdehyde(MDA),the activity of superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) in brain tissue of rats with focal cerebral ischemia reperfusion.Results The conten... |
| Keywords: | D-polymannuronicate malondialdehyde superoxide dismutase glutathione peroxidase |
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