| 急性ST段抬高性心肌梗死患者直接经皮冠状动脉介入术前后11，12-EET变化及意义 |
| |
| 引用本文： | 秦桥基,付研,常静.急性ST段抬高性心肌梗死患者直接经皮冠状动脉介入术前后11，12-EET变化及意义[J].中国急救医学,2008,28(10):899-902. |
| |
| 作者姓名： | 秦桥基 付研 常静 |
| |
| 作者单位： | 首都医科大学附属北京同仁医院急诊科,北京,100176 |
| |
| 基金项目： | 北京市教委科技发展计划 |
| |
| 摘 要： | 目的 观察血清11,12-EET水平在急性ST段抬高性心肌梗死(STEMI)患者行经皮冠状动脉介入术(PCI)前后的变化并初步探讨内源性11,12-EET在心肌缺血/再灌注损伤中的保护效应.方法 13例急性STEMI患者(A组)自入院即刻和行急诊PCI后6 h采集标本,同期行冠状动脉造影(CAG)提示为冠状动脉粥样硬化的患者10例为B组,选取我院体检中心健康查体者10例为C组,所有受检者均抽取静脉血,离心后取血清用高效液相色谱分析法测定血清11,12-EET.结果 急诊PCI后6 h(A2组)血清11,12-EET水平明显高于入院即刻(A1组)、B组及C组血清EET水平,差异有统计学意义(P＜0.01);介入后无再灌注性心律失常患者血清11,12-EET水平高于发生再灌注性心律失常患者血水11,12-EET水平,差异有统计学意义.结论 ①急性STEMI患者行PCI后6 h血清EET水平升高,提示缺血/再灌注损伤可导致血清EET水平的升高;②介入后血清EET水平越高,其缺血/再灌注并发症发生率可能性就越低,提示血清EET可能对缺血/再灌注具有保护效应.
|
| 关 键 词： | 环-二十碳三烯酸 急性ST段抬高性心肌梗死 经皮冠状动脉介入术 |
Significance and change of serum 11,12-EET level before and after the PCI in the patients with acute ST segment elevation myocardial infarction |
| |
| QIN Qiao-ji,FU Yan,CHENG Jing.Significance and change of serum 11,12-EET level before and after the PCI in the patients with acute ST segment elevation myocardial infarction[J].Chinese Journal of Critical Care Medicine,2008,28(10):899-902. |
| |
| Authors: | QIN Qiao-ji FU Yan CHENG Jing |
| |
| Institution: | QIN Qiao-ji,FU Yan,CHENG Jing.Department of Emergency,Beijing Tongren Hospital,Beijing 100176,China |
| |
| Abstract: | Objective To observe the changes of the serum 11,12-epoxyeicosatrienoic acid(EET) level before and after the percutaneous coronary intervention(PCI) in the patients with acute ST segment elevation myocardial infarction(STEMI) and to ascertain the protective effect of 11,12-EET in the patients with acute STEMI.Methods 13 patients with acute STEMI who received direct PCI(group A) and 10 patients who were diagnosed as coronary atherosclerosis by CAG(group B) were studied,10 persons were chosen from the medical... |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
