TGF-β/BMP信号通路在心脏流出道发育中的作用

心脏圆锥动脉干畸形是复杂型先天性心脏病最常见的形式,其中心脏流出道对于圆锥动脉干的发育起到了至关重要的作用.转化生长因子β/骨形态发生蛋白信号通路目前成为研究的热点之一,被认为是心脏发生过程中多个环节的重要调节机制,其中包括流出道的分隔和瓣膜的成熟等.了解这个信号通路的功能及其与心脏流出道发育的关系,将有助于进一步地阐述圆锥动脉干畸形的发病机制.

The role of TGF-β/BMP signaling pathway in the development of cardiac outflow tract

Conotruncal anomaly is composed of a group of complex congenital heart diseases. Cardiac outflow tract (OFT) plays an essential role in the cardiac conotruncal development. Recently, transforming growth factor β/bone morphogenetic protein signaling pathway has become a research hotspot, which is recognized as a important regulation mechanism in many processes of the cardiac development, such as separation of OFT and maturation of septums. In this paper we describe the role of the signaling pathway and its effect on the development of cardiac OFT.