| 京都酚的致惊作用 |
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| 引用本文： | 史凌云 库宝善. 京都酚的致惊作用[J]. 中国药理学与毒理学杂志, 1991, 5(3): 171-173 |
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| 作者姓名： | 史凌云 库宝善 |
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| 作者单位： | 北京医科大学药理教研室，北京医科大学药理教研室 北京 10008，北京 10008 |
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| 基金项目： | 国家自然科学基金 No 3870876 |
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| 摘 要： | 京都酚为-中枢神经系统活性二肽,icv可使小鼠出现惊厥。右旋京都酚致惊活性明显强于左旋体。利血平化动物明显增强京都酚的致惊作用,对于京都酚在利血平化小鼠所引起的惊厥,L-Dopa可使之减弱。5-HTP及纳洛酮可使之增强;抗癫痫药中硝基安定、苯妥英钠和丙戊酸钠可明显延长发作潜伏期,缩短持续时间和减少发作率。
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| 关 键 词： | 京都酚 致惊作用 利血平 小鼠 抗癫痫药物 |
Convulsive action of kyotorphin in mice |
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| SHI Ling-Yun,KU Bao-Shan. Convulsive action of kyotorphin in mice[J]. Chinese Journal of Pharmacology and Toxicology, 1991, 5(3): 171-173 |
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| Authors: | SHI Ling-Yun KU Bao-Shan |
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| Affiliation: | SHI Ling-Yun,KU Bao-Shan Department of Pharmacology,Beijing Medical University,Beijing 100083 |
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| Abstract: | Kyotorphin (KTP) which was found as a dipeptide in the CNS, induced convulsion in mice. The convulsive activity of D-KTP was greater than that of L-KTP when administered by icv. A marked convulsive activity of D-KTP was observed in the reserpinized mice. L-Dopa, if pretreated, could decrease the mortality, whereas 5 HTP and naloxone in-crease it. In the antiepileptics, nitrazepam, sodium phenytoin and sodium valproate could prolong the latent period, shorten the duration and decrease the rate of convulsion significantly. |
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| Keywords: | kyotorphin convulsive activity reserpine mouse antiepileptics |
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