| 精神药物之间经P450 3A4酶的相互作用 |
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| 引用本文： | 徐捷. 精神药物之间经P450 3A4酶的相互作用[J]. 国外医学:老年医学分册, 2010, 0(6): 279-283 |
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| 作者姓名： | 徐捷 |
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| 作者单位： | 南京医科大学附属脑科医院,中国南京210029 |
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| 摘 要： | 氟哌啶醇、奎硫平、阿立哌唑、瑞波西汀、卡马西平、三唑仑、咪达唑仑、地西泮、阿普唑仑、佐匹克隆、唑吡坦和坦度螺酮主要经3A4酶代谢，氟西汀、氟伏沙明、帕罗西汀和舍曲林抑制3A4酶活性，而卡马西平、苯妥英、普里米酮和利福平诱导3A4酶活性。
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| 关 键 词： | 3A4酶 抑制 诱导 血药浓度 精神药物 |
The Intereaction of Psychoactive Drugs by P4503A4 - enzyme |
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| Xu Jie. The Intereaction of Psychoactive Drugs by P4503A4 - enzyme[J]. Foreign Medical Sciences(Geriatrics), 2010, 0(6): 279-283 |
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| Authors: | Xu Jie |
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| Affiliation: | Xu Jie (Brain Hospital, Nanjing Medical University, Nanjing 210029, China) |
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| Abstract: | Holoperidol, Carbamazepine, Alprazolam and so on are metabolized by 3A4 - enzyme. Fluoxetine, Fluroxamine and so on inhibit 3A4 - enzyme activity And Carbamazepine, Phenytoin and Rifampin induce the activity of 3A4 - enzyme. |
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| Keywords: | 3A4 - enzyme Inhibition Induction Blood concentration Psychoactive drug |
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