Autoimmune Hemolytic Anemia in Hodgkin's Disease Associated with Anti-IT

In this study, three cases of Hodgkin's disease with autoimmune hemolytic anemia are described. The IgG autoantibodies in each case were shown to have I^T specificity. There is only one other case of an IgG anti-I^T described in the literature and that also was present in a patient with Hodgkin's disease. No other examples of anti-I^T were found in studies which included 50 cases of Hodgkin's disease with negative direct antiglobulin tests, three cases with positive direct antiglobulin test but no hemolysis, and 70 cases of autoimmune hemolytic anemia, either idiopathic or secondary to other diseases of the reticuloendothelial system. Fetal, cord and adult cells were tested with anti-IT, anti-I and anti-i in an attempt to show the development of I^T relative to i and I.