Biotransformation of hepatic xenobiotics in rats with various resistance to hypoxia exposure to after cold |
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| Authors: | O. R. Grek Yu. P. Gichev E. O. Guseva V. I. Sharapov |
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| Affiliation: | (1) Laboratory of Clinical Problems of Ecology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk;(2) Department of Pharmacology, Novosibirsk Medical Institute, Novosibirsk, USSR |
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| Abstract: | Hepatic monooxygenase activity was studied in rats with various resistance to hypoxia during adaptation to cold. Cold-induced change in the concentrations of cytochromes P-450 and b5 and the activity of microsomals metabolism of amidopyrine and aniline were shown to be associated with individual resistance to hypoxia. The content of microsomal cytochromes in highly resistant rats did not change on the fifth day of cold exposure. However, the intensity of metabolic reactions decreased. In low-resistance rats, a cold-induced decrease in the concentration of the cytochromes was not accompanied by significant changes in metabolic rates of amidopyrine and aniline. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 631–633, December, 1998 |
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| Keywords: | individual resistance to hypoxia hepatic monooxygenases cold adaptation |
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