| 大鼠酒精性肝损伤模型的建立及病理学观察 |
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| 引用本文： | 李东良,郭红哲,杨才生,黄爱琼,陈紫榕. 大鼠酒精性肝损伤模型的建立及病理学观察[J]. 中西医结合肝病杂志, 2000, 10(2): 30-31 |
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| 作者姓名： | 李东良 郭红哲 杨才生 黄爱琼 陈紫榕 |
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| 作者单位： | 1. 解放军476中心医院肝病研究所,福州,350002
2. 山西职工医学院 |
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| 摘 要： | 目的：为研究酒精性肝病（ＡＬＤ）提供理想的动物模型。方法：模型组大鼠１２只，采用５０％酒精每日２次灌胃，同时给予酒精饮料饲养，连续１４周，建立慢性酒精性肝损伤大鼠模型；应用光镜观察酒精对大鼠肝组织及超微结构的影响。结果：模型组所有大鼠均出现了脂肪肝；９１．６％的动物发生了酒精性肝炎，部分大鼠（１６．７％）可见肝脏间质反应性增生；对照组大鼠肝组织及超微结构均正常。结论：该方法可造成具有类似于人类ＡＬ
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| 关 键 词： | 酒精性肝病 大鼠模型 病理学 |
| 修稿时间： | 1999-11-19 |
Modelling the Chronic Alcoholic Liver Disease (ALD) in Rat and Its Pathologic Observation |
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| Li Dongliang,Guo Hongzhe,Yang Caisheng,et al.. Modelling the Chronic Alcoholic Liver Disease (ALD) in Rat and Its Pathologic Observation[J]. Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases, 2000, 10(2): 30-31 |
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| Authors: | Li Dongliang Guo Hongzhe Yang Caisheng et al. |
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| Affiliation: | Li Dongliang,Guo Hongzhe,Yang Caisheng,et al.Institiute for Liver Disease,476 Hospital of PLA |
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| Abstract: | Aim: To provide an ideal animal model of ALD in rat. Method: The chronic ALD was modelled in 12 rats, by means of gastrolavaging 50% alcohol twice a day and feeding alcohol beverage during 14 weeks. As the control group (12 rats), water instead of alcohol was gastrolavaged and fed in the same one. Then the pathologic change of hepatic tissue in both groups was observed respectively in light microscope and electronic microscope. Results: In the model group. all the rats appeared fatty liver. 91. 6% arised alcoholic hepatitis. 16. 7% showed reactive hepatic interstitial proliferation; No pathologic change was found in the control group. Conclusion: The modelling in rat was proved successful,which high similar to the chronic ALD in human. |
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| Keywords: | Alcoholic Liver Disease (ALD) Animal Model Rat Pathology |
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