Inhibitory effect of drug-free hybrid liposomes on metastasis of human neuroblastoma |
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| Authors: | Yoshizawa Jyoji Negishi Yuka Matsumoto Yoko Ueoka Ryuichi Ohki Takao |
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| Institution: | (1) Department of Surgery, Jikei University School of Medicine, Tokyo, Japan;(2) Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan |
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| Abstract: | Purpose Hybrid liposomes composed of vesicular and micellar molecules have been used as drug-delivery systems. It has become clear
that hybrid liposomes alone have an inhibitory effect against the growth of various tumor cells. The present study was designed
to determine whether a drug-free hybrid liposome composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylenealkyl
ether (EO) 90 mol% DMPC/10% C12(EO)21 (HL21), 90 mol% DMPC/10% C12(EO)23 (HL23), or 90 mol% DMPC/10% C12(EO)25 (HL25)], inhibit the liver metastasis of human neuroblastoma cells and thus increases survival. |
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