异丙酚对大鼠胃缺血再灌注损伤的影响

目的观察异丙酚对大鼠胃缺血再灌注损伤（gastricischemia—reperfusion injury，GI—RI）的影响。方法30只SD大鼠，随机分为3组，假手术组（S组）、单纯缺血-再灌注组（I—R组）、异丙酚组（P组）。以夹闭大鼠腹腔动脉30min、松开动脉夹恢复血流灌注1h制备GI—RI模型。计算胃黏膜损伤指数，检测胃黏膜超氧化物歧化酶（supemxide dismutase，SOD）活性和丙二醛（malondialdehyde，MDA）含量。结果静脉注入异丙酚后，胃缺血再灌注导致的胃黏膜损伤减轻，胃黏膜损伤指数明显减少，异丙酚组（P组）与缺血一再灌注组（I—R组）比较，胃黏膜中MDA含量下降，SOD活性升高。结论异丙酚对GI—RI具有明显的保护作用。这种保护作用可能是通过异丙酚的抗氧化作用实现的。

Effects of propofol on gastric ischemia-reperfusion injury in rats

Objective To investigate the effect of propofol on gastric ischemia-reperfusion injury (GI-RI). Methods Sprague-Dawley rats were randomly divide into 3 groups: Sham-operation group, GI/RI control group, and GI/R plus propofol group. A rat model of GI-RI was established by clamping the celiac artery for 30 min and allowing reperfusion for l h, on which gastric mucosa damage index, the activity of superoxide dismutase (SPD) and the content of malondialdehyde (MDA) of gastric mucosa were investigated. Results Propofol obviously attenuated gastric mucosa injury induced by gastric ischemia-reperfusion and reduced the gastric mucosal damage index (GMDI). From the comparison of GI/R plus propofol group with GI/RI control group, propofol obviously attenuated the GI-RI, increased the activity of SOD but decreased the content of MDA of gastric mucosa. Conclusions WTBZ]Proporol has the protective effects on GI-RI by its anti-oxidation.