Efficacy and safety of oral sildenafil in men with erectile dysfunction and spinal cord injury |
| |
Authors: | Gans W H Zaslau S Wheeler S Galea G Vapnek J M |
| |
Institution: | Department of Urology, Mount Sinai Medical Center, New York, NY 10029, USA. |
| |
Abstract: | OBJECTIVE: To assess the efficacy of sildenafil in men with spinal cord injury (SCI) and erectile dysfunction (ED). METHODS: Seventeen men with SCI were selected from February to September 1998 for sildenafil treatment of ED. The initial dose of 25 mg was increased by 25-mg increments as needed. Patients underwent baseline physical examination and answered questions from the abridged International Index of Erectile Function before and during therapy. RESULTS: Sixteen patients tolerated therapy; 1 developed hypotension and discontinued therapy. There was significant improvement in erectile function (P < .05) after 5.3 +/- 2.2 months when compared with baseline or previous therapies (P < .05). Of the 17 patients, 94% recommended sildenafil to others. Six of these 16 patients were available for long-term follow-up. There was further significant improvement in quality of erection (P < .05), but no change in satisfaction. CONCLUSION: Sildenafil is effective and well tolerated in men with SCI and ED. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|