新生儿血清骨碱性磷酸酶、骨钙蛋白和瘦素水平的检测及临床意义

目的：探讨早期诊断新生儿代谢性骨病的敏感指标。方法：选择新生儿90例，在生后1d内及第14天采集空腹静脉血。生化法检测血清钙、磷水平；酶联免疫分析测定法检测血清骨碱性磷酸酶（BAP）、骨钙蛋白（OC）和瘦素（Leptin）水平。结果：胎龄越小，BAP水平越高，OC水平越低，Leptin水平越低；胎龄32周以下的早产儿骨矿化不活跃；胎龄32周以上的早产儿骨骼生长速度趋于平稳上升，水平接近足月新生儿。结论：BAP水平的异常增高和血磷的降低是早期诊断新生儿代谢性骨病的敏感指标；OC可作为钙缺乏性佝偻病和维生素D缺乏性佝偻病的重要鉴别指标。

Level Changs and Clinical Significance of Serum BAP、OC and Leptin in Newborns

Objective：To observe the changes of serum BAP,OC and Leptin in newborns in different gestation ages, to choose ideal diagnostic marker of metabolic bone disease. Methods：All the newborns were divided in three groups according to gestational age ：The blood samples were obtained within ld after birth and 14d after birth. BAP,OC and Leptin were determined by EI,ISA. Results：BAP, OC and Leptin participated in neonatal bone metablism. Bone metabolism of premature infants whose GA〈32 weeks were bone mineralization inactive;bone formation of premature infants whose GA〈32 weeks were steady to rise. Conclusions：BAP and P are an ideal diagnostic marker to early identify metabolic bone disease. OC may be important identify index between ealcipenic rickets anf vitamin D deprivation rickets.