Leualacin, a novel calcium blocker from Hapsidospora irregularis. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. |
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| Authors: | K Hamano M Kinoshita K Furuya M Miyamoto Y Takamatsu A Hemmi K Tanzawa |
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| Affiliation: | Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. |
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| Abstract: | A new calcium blocker, designated leualacin, has been isolated from Hapsidospora irregularis. The compound inhibits the binding of 3H-nitrendipine, a well known synthetic calcium blocker, to cardiac Ca channel in a competitive manner, although its structure is completely different from dihydropyridines. |
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