定量组织速度成像技术对心肌致密化不全患者心肌同步性的研究

目的应用定量组织速度成像技术（QTVI）评价心肌致密化不全（NVM）患者左室心肌收缩及舒张同步性情况。方法采用组织速度成像技术采集18例NVM患者及18例正常对照者的心尖3个切面的QTVI图像。分别脱机描绘6个壁基底段及中间段共12个节段组织速度曲线并测量收缩期达峰时间（Ts）和舒张早期达峰时间（Te）,计算每一受检查者左室12个节段的Ts最大差值、收缩速度峰值时间的标准差（Ts-s）及Te最大差值、舒张早期速度峰值时间的标准差（Te-s）。结果以12个节段的Ts、Te最大差值〉100ms为收缩及舒张不同步,心肌致密化不全患者收缩及舒张不同步分别有15例（83%）、11例（61%）。以Ts-s〉32.6ms、Te-s〉30.1ms为收缩及舒张不同步,心肌致密化不全患者收缩及舒张不同步分别为15例（83%）、12例（67%）。结论NVM患者存在较明显的收缩及舒张不同步,且其收缩期不同步性与病变累及的解剖部位存在一定的关系。

Quantitative Tissue Velocity Imaging Detecting Left Ventricular Systolic and Diastolic Asynchrony in Patients with Noncompaction of Ventricular Myocardium

Objective We attempted to investigate the occurrence of left ventricular systolic and diastolic asynchrony in patients with noncompaction of ventricular myocardium(NVM)using quantitative tissue velocity imaging.Methods The study population consisted of 18 patients with NVM diagnosed on echocardiography and/or magnetic resonance imaging and 18 healthy subjects.The velocity curves were obtained in 6 basal segments and 6 middle ones in the apical images.The maximal difference in time to peak myocardial systolic velocity(Ts)and to early diastolic velocity(Te),and the standard deviations of Ts(Ts-SD)and Te(Te-SD)were measured and calculated in 12 left ventricular segments for each subject.Results Compared with the healthy subjects,in patients with NVM,the maximal diflerence in Ts was significantly prolonged,Ts-SD significantly greater,and the maximal difference of Te,(Te-dif)Te-SD prolonged with all P<0.001.Conclusions Left ventricular systolic and diastolic mechanical asynchrony is common in patients with NVM.Left ventricular systolic asynchrony in patients with NVM is consistent with anatomic distribution of noncompaction myocardium.