| 颈静脉内照射光动力学疗法对大鼠血液成分的影响 |
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| 引用本文： | 董霞,王欢,张红雨,孙媛媛,李迎新.颈静脉内照射光动力学疗法对大鼠血液成分的影响[J].中国激光医学杂志,2007,16(2):79-81. |
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| 作者姓名： | 董霞 王欢 张红雨 孙媛媛 李迎新 |
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| 作者单位： | 天津医科大学激光医学实验室,天津市,300070 |
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| 基金项目： | 天津市应用基础重点基金;国家自然科学基金 |
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| 摘 要： | 目的 探讨血管内照射光动力学疗法对大鼠血液成分的影响。
方法 Wiser大鼠32只随机分成4组，每组8只。3个实验组，分别经尾静脉注射HpD1、5和25mg，以功率为5mW的630nm半导体激光，颈静脉血管内照射。另设不做任何处理的正常对照组。于实验第3和6小时取血检查WBC、RBC、HGB、HCT、MCV、PLT、W-SCR。
结果 在HpD浓度为5mg／ml，激光功率5mW，照射时间30min，血液指标无损伤性变化。
结论 提示在一定条件下照射在体光动力学疗法对血液成份无危害性影响。
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| 关 键 词： | 光动力学疗法 血液照射 血常规 大鼠 |
| 文章编号： | 1003-9430（2007）02-0079-03 |
| 收稿时间： | 2006-09-13 |
| 修稿时间： | 2006年9月13日 |
Effect on Rat Blood by Photodynamic Therapy with Irradiation via Mice Jugular Vein |
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| DONG Xia,WANG Huan,ZHANG Hong-yu,SUN Yuan-yuan,LI Ying-xin.Effect on Rat Blood by Photodynamic Therapy with Irradiation via Mice Jugular Vein[J].Chinese Journal of Laser Medicine & Surgery,2007,16(2):79-81. |
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| Authors: | DONG Xia WANG Huan ZHANG Hong-yu SUN Yuan-yuan LI Ying-xin |
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| Institution: | Laser Medicine Laboratory, Tianjin Medical University, Tianjin 300070, China |
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| Abstract: | Objective To study the effect on normal blood index by photodynamic therapy with irradiation on blood.Methods The blood was irradiated via jugular vein with three doses of HpD(separately 1,5 and 25mg/ml,1ml to every rat)injected through caudal vein,the blood routine examination was conducted and the effect of PDT was analyzed.Results The experiment showed that blood index had no damaging changes under certain concentration of HpD and intensity of light(HpD:5mg/ml,laser power: 5mW,irradiated time: 30min).Conclusions The result shows that photodynamic therapy through irradiating the blood has no damaging effect under certain condition. |
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| Keywords: | Photodynamic therapy Irradiation on blood Blood routine examination Rat |
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