| 糖尿病周围神经病变疼痛机制研究进展 |
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| 引用本文： | 王汉兵,王焱林,杨承祥. 糖尿病周围神经病变疼痛机制研究进展[J]. 国际麻醉学与复苏杂志, 2007, 28(2): 162-165 |
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| 作者姓名： | 王汉兵 王焱林 杨承祥 |
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| 作者单位： | 1. 528000,佛山,中山大学附属佛山医院麻醉科
2. 武汉大学附属中南医院麻醉科 |
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| 摘 要： | 痛性糖尿病周围神经病变（DPN）表现为对多数镇痛药物的抵抗。最近许多研究表明，背根神经节（DRG）钠离子通道、丝裂原激活蛋白激酶、一氧化氮、蛋白激酶C、去甲肾上腺素等在DPN疼痛信号转导和痛觉调制方面发挥重要作用。现就DPN疼痛的分子机制及治疗前景作一探讨。
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| 关 键 词： | 糖尿病 神经病变 背根神经节 疼痛 |
Advance of mechanism in painful diabetic peripheral neuropathy |
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| WANG Han-bing,WANG Yan-lin,YANG Cheng-xiang. Advance of mechanism in painful diabetic peripheral neuropathy[J]. international journal of anesthesiology and resuscitation, 2007, 28(2): 162-165 |
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| Authors: | WANG Han-bing WANG Yan-lin YANG Cheng-xiang |
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| Affiliation: | Department of anesthesiology , Foshan hospital of Zhongshan university, Foshan 528000, China |
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| Abstract: | It is widely known that patients with painful diabetic peripheral neuropathy demonstrate refractory to most of analgesic agents, even including opioids. Many late researches have shown that TrX-R sodium currents in neurons of dorsal root ganglion, mitogen activated protein kinase, nitrogen oxide, protein kinase C, as well as noradrenaline all play an important roles both in nociceptive signal transduction and in nociceptive modulation. This article reviews the development of molecular mechanism responsible for painful diabetic neuropathy and the prospect of treatment strategy. |
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| Keywords: | diabetic neuropathy dorsal root ganglion pain mechanism |
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