| 咪达唑仑鼻用凝胶喷雾剂的镇静催眠作用研究 |
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| 引用本文： | 王 静,盖宇清,高建义,刘军莲,薛春美,辛冰牧,李勇枝.咪达唑仑鼻用凝胶喷雾剂的镇静催眠作用研究[J].药学与临床研究,2010,18(2):145-148. |
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| 作者姓名： | 王 静 盖宇清 高建义 刘军莲 薛春美 辛冰牧 李勇枝 |
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| 作者单位： | 中国航天员科研训练中心,北京,100094 |
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| 基金项目： | 中国载人航天工程预先研究项目 |
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| 摘 要： | 目的：对咪达唑仑鼻用凝胶喷雾剂的镇静催眠作用进行初探。方法：采用镇静、催眠实验，考察味达唑仑通过经鼻腔给药途径对小鼠自发活动和对戊巴比妥钠催眠作用的影响，以及对小鼠抬举双前肢的影响。结果：咪达唑仑鼻用凝胶喷雾剂经鼻腔给药后，可明显降低小鼠的自主活动次数，并具有良好的量效关系；可极显著地使阂下剂量戊巴比妥钠导致小鼠的入睡只数增加；各剂量组均可明显缩短给予戊巴妥钠阈上剂量后小鼠的入睡时间并延长其睡眠时间；可明显减少2min内小鼠的抬举双前肢的次数．结论：味达唑仑鼻用凝胶喷雾剂具有明显的镇静催眠作用．
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| 关 键 词： | 咪达唑仑鼻用喷雾剂 镇静 催眠 |
| 收稿时间： | 2009/5/11 0:00:00 |
| 修稿时间： | 2010/1/21 0:00:00 |
Study on the Sedative and Hypnotic Effects of Midazolam |
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| WANG Jing,GAI Yu-qing,GAO Jian-yi,LIU Jun-lian,XUE Chun-mei,XIN Bing-mu and LI Yong-zhi.Study on the Sedative and Hypnotic Effects of Midazolam[J].Pharmacertical and Clinical Research,2010,18(2):145-148. |
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| Authors: | WANG Jing GAI Yu-qing GAO Jian-yi LIU Jun-lian XUE Chun-mei XIN Bing-mu and LI Yong-zhi |
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| Institution: | China Astronaut Research and Training Center, Beijing 100194, China;China Astronaut Research and Training Center, Beijing 100194, China;China Astronaut Research and Training Center, Beijing 100194, China;China Astronaut Research and Training Center, Beijing 100194, China;China Astronaut Research and Training Center, Beijing 100194, China;China Astronaut Research and Training Center, Beijing 100194, China;China Astronaut Research and Training Center, Beijing 100194, China |
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| Abstract: | Objective: To evaluate the sedative and hypnotic effects of midazolam. Methods: The effects of midazolam as sedative and hypnotics were studied by observing the spontaneous behavior, prolonged sleeping time cooperated with pentobarbital sodium and time of |
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| Keywords: | Midazolam Sedation Hypnotism Mice |
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