186株铜绿假单胞菌医院内感染分析

目的:了解铜绿假单胞菌的医院内感染现状及其耐药性变化,为临床合理用药提供参考。方法:参照美国临床实验室标准化委员会(NCCLS)推荐方法操作。统一采用NCCLS 1999年标准判断药物敏感度,以WHONET-4软件统计耐药率。对2005年—2008年临床分离出的186株铜绿假单胞菌的药敏试验进行分析。结果:铜绿假单胞菌感染主要发生在重症监护病房(27.42%)和呼吸门诊(24.19%);感染部位主要是呼吸道58.60%(109/186)和伤口30.06%(57/186)。铜绿假单胞菌对亚胺培南、哌拉西林/他唑巴坦和头孢他啶耐药率均<14%。结论:危重患者是铜绿假单胞菌感染的易感人群,临床有轻度感染可选用AMK、ATM、CFP等耐药率变化较低的抗菌药物;同时临床应加强耐药性检测与药敏分析工作。

Analysis of Resistance of 186 Strains of Pseudomonas Aeruginosa to Antibiotics

Objective： To study the current situation and drug resistance of nosocomial infection caused by Pseudomonas aeruginosa, and to provide reference for clinical rational drug use. Methods： referring to the U.S. Committee for Clinical Laboratory Standards （NCCLS） recommended method. Using 1999 standard of NCCLS uniformly to deten-nine the drug sensitivity, and to get the statistics of drug resistant rotes by WHONET-4 Software. To analyze the drug resistence of 186 cases of clinical isolated pseudomonas aeruginosa from 2005 to 2008. Results： Pseudomonas aeruginosa infection mainly occurred in the intensive care trait（27.42%） and respiration outpatient service （24.19%）; Mainly infection site is respiratory tract（58.60%, 109/186） and wound （30.06%, 57/186）. the resistance rate ofPseudomonas aeruginosa to imipenem, piperacillin / tazobactam and cefiazidime is less than 14%. Conclusion： The susceptible population of Pseudomonas aeruginosa infection is critically ill patients; a mild clinical infection may choose AMK, ATM, CFP and other antibacterial drugs which changes in rates of lower resistance. We should strengthen the drug resistance testing and durg sensitivity analysis clinically .