侧茎橐吾化学成分的研究

目的侧茎橐吾（Ligularia pleurocaulis）为菊科橐吾属植物，其根和根茎入药，有止咳化痰、活血化瘀等功效，为中药“紫菀”（中国药典2000年版收载为Aster tataricus L.f.的根及根茎）的代用品之一，称为“山紫菀”。有关侧茎橐吾的化学成分研究尚未见报道，因此，本文对侧茎橐吾的根及根茎的化学成分进行了研究。方法侧茎橐吾的根和根茎用甲醇提取，硅胶柱色谱和重结晶等方法进行分离纯化。根据化合物的理化性质和光谱数据进行结构鉴定。结果分离得到了12个化合物，即6-angeloyloxy-furanoligularenone (1)，2-oxo-3-hydroxy-eremophila-1(10),3,7(11),8-tetraen-8,12-olide (2)，顺芷酸(3)，齐墩果酸(4)，羽扇豆醇(5)，β-谷甾醇(6)，胡萝卜苷(7)，咖啡酸(8)，大黄素(9)，7-甲氧基香豆素(10)，阿魏酸(11)和4-羟基-2,5-二甲氧基-苯甲醛(12)。结论化合物1为新的eremophilane型倍半萜，化合物2为新的天然产物。所有化合物均为首次从本植物中得到。

The chemical constituents of Ligularia pleurocaulis

AIM: To study the chemical constituents of the underground part of Ligularia pleurocaulis (Franch.) Hand-Mazz. METHODS: The dried roots and rhizomes of L. pleurocaulis were extracted with methanol. Isolation and purification were performed by silica gel column chromatography and recrystallization etc. Structures of the pure compounds were established on basis of spectral analysis. RESULTS: Twelve compounds were obtained from L. pleurocaulis, they were 6-angeloyloxy-furanoligularenone (1), 2-oxo-3-hydroxy-eremophila-1(10),3,7(11),8-tetraen-8,12-olide (2), tiglic acid (3), oleanolic acid (4), lupeol (5), beta-sitosterol (6), daucosterol (7), caffeic acid (8), emodin (9), 7-methoxy-coumarin (10), ferulic acid (11) and 4-hydroxy-2,5-dimethoxy-benzaldehyde (12). CONCLUSION: Compound 1 is a new eremophilane and compound 2 is a new natural compound. All above compounds were obtained for the first time from L. pleurocaulis.