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| P-gp及对抗P-gp介导多药耐药的研究现状 | |
| 引用本文： | 马秉亮,吴玉林,刘国卿. P-gp及对抗P-gp介导多药耐药的研究现状[J]. 中国临床药理学与治疗学, 2006, 11(1): 14-21 |
| 作者姓名： | 马秉亮 吴玉林 刘国卿 |
| 作者单位： | 1. 上海中医药大学中药学院药理学教研室,上海,201203 2. 中国药科大学药学院生理学教研室,南京,210038,江苏 3. 中国药科大学药学院药理学教研室,南京,210038,江苏 |
| 摘 要： | P-糖蛋白在多药耐药中起着重要的作用。本文就P-gp的蛋白结构、作用机制及其与多药耐药的关系以及对抗P-gp介导的MDR的现状做了简要介绍。总之，一方面要继续开发高效的P-gp抑制剂，同时，又要考虑过度抑制P-gp可能会带来不良影响；在抑制P-gp的同时，还要兼顾对其它耐药机制的抑制，只有这样，才能在临床上充分解决多药耐药的问题。 |
| 关 键 词： | P-糖蛋白 多药耐药 抑制剂 基因表达 |
| 文章编号： | 1009-2501(2006)01-0014-08 |
| 收稿时间： | 2005-09-15 |
| 修稿时间： | 2005-10-31 |
Progress in anti-multidrug resistance mediated by p-glycoprotein |
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| MA Bing-liang,WU Yu-lin,LIU Guo-qing. Progress in anti-multidrug resistance mediated by p-glycoprotein[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(1): 14-21 | |
| Authors: | MA Bing-liang WU Yu-lin LIU Guo-qing |
| Affiliation: | Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China ; 1 Department of Physiology;2 Department of Pharmacology, China Pharmaceutical University, Nanfing 210038, Jiangsu, China |
| Abstract: | P-glycoprotein(P-gp) plays an important role in multidrug resistance(MDR).This article was focused on the protein structure and the mechanism of P-gp,and especially on the current status in anti-P-gp drug research and discovery.The action of P-gp in MDR was also reviewed.Moreover,the potential adverse reaction of P-gp inhibitors were emphasized since P-gp was involved in the normal function of a lot of organs. |
| Keywords: | p-glycoprotein multidrug resistance inhibitors gene expression |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |