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Effects of noradrenaline on some potassium currents in CA1 neurones in rat hippocampal slices |
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| Authors: | P. Sah C.R. French P.W. Gage |
| Affiliation: | Dept. of Physiology, John Curtin School of Medical Research, Australian National University, Canberra City, A.C.T., Australia |
| Abstract: | Pyramidal (CA1) cells in rat hippocampal slices were voltage clamped using a single electrode voltage clamp. In the presence of tetrodotoxin (TTX), depolarizing pulses from holding potentials of −60 to −70 mV elicited a slow inward calcium (Ca2+) current and two outward potassium (K+) currents: an A current and a slower, Ca2+-dependent K+ current. Noradrenaline (NA) (20 μM) depressed the amplitude of the K+ currents without affecting the Ca2+ current. The effect of NA could be blocked with propranolol and was mimicked by isoprenaline, suggesting that NA depresses the K+ currents by binding to β-receptors. |
| Keywords: | rat hippocampus voltage clamp noradrenaline potassium current |
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