Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection |
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Authors: | Natacha Colliou Yong Ge Minghao Gong Mojgan Zadeh Jing Li Francis Alonzo III |
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Institution: | 1. Department of Infectious Diseases &2. Immunology, University of Florida, Gainesville, FL, USA;3. Division of Gastroenterology, Hepatology &4. Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USA;5. Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA |
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Abstract: | Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes (L. m), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability of P. UF1 bacterium derived from the intestinal bacterial commensals of preterm infants fed human breast milk to significantly mitigate pathogen-induced inflammation limiting colonic tissue damage. Here we further elucidated the potential of P. UF1 to also regulate innate and T cells, particularly Th17 and Th1 cells, against systemic L. m infection. Data demonstrate that P. UF1 not only robustly regulated protective Th17 and Th1 cells, but also sustained regulatory T cells (Treg cells) resulting in accelerated L. m clearance. Together, regulation of pathogenic inflammation by a novel probiotic bacterium such as P. UF1 may illuminate a new strategy to specifically control Th17-Th1 cells via IL-10+ Treg cells to limit systemic tissue damage induced by intracellular pathogens, including L. m. |
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Keywords: | P UF1 bacterium Listeria monocytogenes SIGNR1 Th17 cells Th1 cells regulatory T cells mucosal immunity |
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