瘦素、抵抗素、2型糖尿病间的相关性研究

目的：研究血浆瘦素与抵抗素、体重指数、腰围、腰臀比、血脂、胰岛素敏感性指数等的关系。方法：对43例新诊断2型糖尿病患者及37例糖耐量正常者，测定空腹血浆瘦素、胰岛素、血糖、血脂及抵抗素浓度。结果：相关分析显示性别、体重指数（BMI）、腰围、腰臀比、胰岛素与瘦素呈显著正相关（r分别为0.623,0.534，0.516，0.302，0.354，均P<0.01），IAI与瘦素呈显著负相关(r=-0.373,P<0.01),甘油三酯、胆固醇空腹血糖与瘦素无明显相关。瘦素与抵抗素无相关性（r=0.101,P>0.05）结论：空腹血浆瘦素水平与肥胖程度、胰岛素抵抗呈显著正相关，与抵抗素无关。瘦素可能与2型糖尿病的发病有关。

Correlation among plasma leptin,resistin an type 2 diabetes mellitus

AIM: To assess the association of resistin, obesity,serum lipid levels and insulin resistance with plasma leptin.METHODS: The concentrations of fasting serum glucose,insulin,lipid profiles,plasma resistin and leptin were assayed in 80 cases(including 37 controls with normal glucose tolerance and 43 patients with type 2 diabetes mellitus).RESULTS: Fasting plasma leptin level was positively correlated with sex,body mass index(BMI),waist circumference(WC),waist-hip ratio and fasting serum insulin(F Ins)(P<0.01).Fasting plasma leptin level was negatively correlated with insulin sensitivity index(r=(-0.373),P<0.01).There was no correlation between the concentrations of plasma leptin and FPG,TG,TC and resistin(P>0.05).CONCLUSION: Fasting plasma leptin level is positively correlated with obesity and insulin resistance,not resistin.Leptin may play a role in the pathogenesis of type 2 diabetes mellitus.