Un anxiolytique naturel : l’hydrolysat trypsique de caséine alpha-s1 de lait bovin. Son intérêt en médecine humaine et vétérinaire |
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Authors: | M Bénézech E Mullens D Desor |
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Institution: | a 266, rue Judaïque, 33000 Bordeaux, France b Laboratoire du sommeil, Fondation Bon-Sauveur-d’Alby, boulevard du Lude, 81003 Albi, France c Unité de recherche en neurosciences, université de Montréal/Saint-Luc, Québec H2X 3J4, Canada d Équipe de neurosciences comportementales, URAFPA, Inra UC340, INPL-UHP, BP 172, 54505 Vandoeuvre-lès-Nancy cedex, France e Centre de recherche en éthologie appliquée (ETAP), technopôle de Nancy-Brabois, 13, rue du Bois-de-la-Champelle, 54500 Vandoeuvre-lès-Nancy, France |
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Abstract: | Tryptic hydrolysate from bovine milk alpha-s1 casein (THC), a natural product, contains a specific active decapeptide called alpha-casozepine which shows interesting pharmacological properties. Preclinical and clinical trials, as well as tests carried out on both humans and animals (rats, dogs, cats) demonstrated certain qualities of this hydrolysate. It shows a marked affinity for GABA-A receptors with a benzodiazepine-like profile and a tranquilizing and antistress activity associated with good tolerance characterized, in particular, by the absence of any habituation, dependence, sedation, memory impairment and toxicity. THC is a nutritional supplement (French regulatory status) which cannot be used as a substitute for psychotropes, such as benzodiazepines, in the treatment of severe anxiety and sleep disorders in respect of the medical recommendations. However, it could be effective in cases of slighter signs of these disorders. It could also be appropriate in the medical prevention and follow-up of subjects who have difficulty adapting to changes and stressful situations of daily life. An original pilot clinical trial respecting good practice and representative of the cases observed by General Practitioners (GPs) showed the interest of a global management program for benzodiazepine withdrawal. This global management program which included the use of THC opened a new application for it in general practice. As a result of a certain neuropsychiatric similarity between man and the domestic dog, we took the opportunity of presenting this natural tranquillizer in its application in both human and veterinary medicine. |
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Keywords: | Alpha-casozé pine Anxié té Effets secondaires Lait Sevrage de benzodiazé pines Sommeil Stress Toxicité |
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