柚苷配基对慢性压迫性损伤引起的大鼠触摸痛及痛觉过敏的影响

目的：研究柚苷配基对慢性压迫性神经损伤模型的镇痛效果。方法：经慢性压迫性损伤建立神经性疼痛大鼠模型后，分别给予模型大鼠25和50mg／kg的柚苷配基以及10mg／kg的普加巴林。在第0、3、5、7、14和21天采用Hargreaves方法评估大鼠的行为变化，针刺实验测试触觉性机械痛觉过敏和经冷水诱发的异常性疼痛，最后测定氧化应激反应参数。结果：柚苷配基能缓解经慢性压迫性损伤诱发的神经性疼痛，减轻脂质过氧化反应，降低一氧化氮水平，恢复还原型谷胱甘肽含量。结论：柚苷配基能缓解坐骨神经损伤引起的疼痛。

Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain

OBJECTIVE： To study the analgesic effects of naringenin on chronic constriction injury （CCI） model oi neuropathic pain. METHODS： After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured. RESULTS： Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione. CONCLUSION： The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.