人巨细胞病毒感染与细胞自噬的关系

人巨细胞病毒与宿主共同进化的漫长过程中，为促进自身的增殖和感染，HCMV也进化出多种策略利用或抵消自噬的影响。自噬是进化上高度保守的细胞降解途径，通过回收细胞质、细胞器和蛋白质以维持细胞内稳态。同时它也可以作为细胞防御机制，直接包裹降解病原体或通过促进先天性和适应性免疫以对抗多种病原体的侵袭。本文将对近年来有关HCMV与自噬关系的研究作一综述。

Relationship between Human Cytomegalovirus Infection and Autophagy

Abstract:In the long process of co-evolution of human cytomegalovirus and host,HCMV has also evolved a variety of strategies to exploit or counteract the effects of autophagy in order to promote its own proliferation and infection.Autophagy is an evolutionarily highly conserved cell degradation pathway that maintains cellular homeostasis by recovering cytoplasm,organelles,and proteins.It can also act as a cellular defense mechanism that directly encapsulates pathogens or promotes invasiveness by a variety of pathogens by promoting innate and adaptive immunity.This article will review recent research on the relationship between HCMV and autophagy.