经颅黑质超声诊断帕金森病的临床评价

目的 通过对帕金森病患者及正常对照组进行经颅超声(transcranial sonography，TCS)检查，结合帕金森病患者的Hoehn Yahr（H Y）分级及帕金森病统一评分量表评分结果，了解我国大陆地区帕金森病患者有无黑质(substantia nigra， SN)回声增强表现。方法 对入选对象进行TCS检查，并对检查结果进行评价。结果 帕金森病患者 SN阳性率明显高于正常对照者（P＜0.05）。帕金森病SN异常组 H Y 分期明显高于帕金森病SN正常组(P＜0.05)，表明帕金森病患者SN高回声面积与H Y分期相关。TCS检查对帕金森病的敏感性为80.5%，特异性为79.9%。结论 我国帕金森病患者SN强回声检出率显著高于对照组，说明我国帕金森病患者也存在SN回声增强这一现象，与国内外报道相一致。TCS检查对帕金森病的诊断具有一定的意义，敏感性及特异性较高。

Transcranial sonography in diagnosis of Parkinson’s disease

Objective To figure out whether patients with Parkinson’s disease in the mainland of China have substantia nigra (SN) echo enhancement through the transcranial sonography (TCS) examination of patients with Parkinson’s disease and the control group, and Parkinson’s Hoehn Yahr(H Y) grading and Parkinson’s disease rating score results.Methods The selected subjects were examined by TCS， and the test results were evaluated. Results The incidence of SN in Parkinson’s disease patients was significantly higher than that in normal control group (P<0.05). The H Y staging of abnormal Parkinson’s group was significantly higher than that of Parkinson’s normal group (P<0.05)， indicating that the area of SN hyperechoic in Parkinson’s disease was associated with H Y staging. The sensitivity of TCS examination to Parkinson’s disease was 80.5%, and specificity 79.9%. Conclusion The detection rate of strong echogenicity of SN in Parkinson’s disease patients in our country is significantly higher than that of control group, indicating that the situation of enhanced SN echo in Parkinson’s patients also exists in our country, which accords with the reports at home and abroad. Considering its high sensitivity and specificity, TCS examination is of great significance to the diagnosis of Parkinson’s diseases.