益生元对2型糖尿病患者糖脂代谢的影响

目的 探讨益生元对2型糖尿病患者血糖血脂代谢的影响，分析益生元在糖尿病进程中的作用。方法 选取2017年1月~2018年3月本院104例2型糖尿病患者，按随机数字表法分为对照组和实验组，每组52例，对照组给予安慰剂，实验组服用益生元，12周后再次检测血液中的血糖血脂生化指标，统计分析服用前后生化指标的变化。结果 实验组服用12周益生元后，患者空腹血糖、餐后2 h血糖、糖化血红蛋白、胆固醇及低密度脂蛋白水平低于治疗前，差异有统计学意义 (P＜0.05)。治疗后实验组糖脂生化指标中空腹血糖、糖化血红蛋白、胆固醇及低密度脂蛋白浓度水平均低于对照组，差异具有统计学意义 (P＜0.05)；治疗后两组餐后2 h血糖、甘油三酯、高密度脂蛋白对比，差异无统计学意义（P＞0.05）。结论 补充益生元有助于降低2型糖尿病患者的空腹血糖、糖化血红蛋白、胆固醇及低密度脂蛋白浓度水平，对2型糖尿病患者的血糖及血脂可能具有积极的作用。

Effect of Prebiotics on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes mellitus

Abstract:Objective To investigate the effect of prebiotics on blood glucose and lipid metabolism in patients with type 2 diabetes mellitus,and to analyze the role of prebiotics in the progression of diabetes.Methods A total of 104 patients with type 2 diabetes mellitus from January 2017 to March 2018 were enrolled.The patients were divided into the control group and the experimental group according to the random number table.52 patients in each group,the control group was given a placebo,and the experimental group was given a prebiotic,after 12 weeks,the biochemical indicators of blood glucose and blood lipids were again detected,and the changes of biochemical indicators before and after taking were statistically analyzed.Results After taking the prebiotics for 12 weeks in the experimental group,the levels of fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,cholesterol and low density lipoprotein in the blood of the patients were lower than those before treatment,the difference was statistically significant(P<0.05).After treatment,the concentration of glycosaminoglycan,glycosylated hemoglobin,cholesterol and low density lipoprotein in the experimental group were lower than the control group,the difference was statistically significant(P<0.05). After treatment,the two groups had 2 h postprandial blood glucose.There was no significant difference in the comparison of triglyceride and high density lipoprotein(P>0.05).Conclusion Supplementation of prebiotics can help reduce the levels of fasting blood glucose, glycosylated hemoglobin,cholesterol and low-density lipoprotein in patients with type 2 diabetes mellitus,and may have a positive effect on blood sugar and blood lipids in patients with type 2 diabetes mellitus.