2017年南通市病毒性腹泻监测结果分析

目的 了解南通市腹泻患者病毒感染情况、流行规律及病原特点。方法 采集哨点医院肠道门诊中腹泻病例的粪便标本，运用荧光定量PCR方法检测轮状病毒、诺如病毒、腺病毒、札如病毒、星状病毒。结果 363份腹泻样本中病毒核酸阳性样本为96份，总阳性率为26.45%，轮状病毒、诺如病毒、星状病毒、扎如病毒、腺病毒均有检出，阳性率分别为14.33%、9.37%、1.38%、0.83%、0.55%，混合感染率为4.13%，均为轮状病毒和诺如病毒GⅡ双重感染。轮状病毒和诺如病毒感染有明显的季节特征，多发生在冬春寒冷季节，以0～10岁儿童为易感人群，轮状病毒感染率女性高于男性。结论 轮状病毒和诺如病毒为主要感染病毒，重点关注冬春季节疫情防控，加强婴幼儿免疫接种，加大监测样本量，加深对病毒性腹泻基因型别的研究，对南通市病毒性腹泻的防控和预警有重要的作用。

Analysis of surveillance results of viral diarrhea of Nantong City in 2017

Objective To understand the viral infection,epidemic patterns and pathogenic characteristics of diarrheal patients in Nantong City. Methods Stool specimens from patients with intestinal diarrhea clinics were collected from sentinel hospitals.Detective method of quantitative fluorescence PCR was used to detect rotavirus, norovirus, adenovirus, zebravirus, and astrovirus. Results There were 96 positive cases for virus RNA among 363 samples, with a total positive rate of 26.45%. Rotavirus, norovirus, astrovirus, zarivirus, and adenovirus were all detected, the positive rates were 14.33%, 9.37%, 1.38%, and 0.83%, 0.55% respectively, mixed infection rate was 4.13%, both rotavirus and Norovirus GII dual infection, rotavirus and norovirus infection has obvious seasonal characteristics, mostly occurred in the cold season of winter and spring, with children aged 0-10 years were susceptible to infection,and rotavirus infection rates are higher among women than men. Conclusion Rotavirus and norovirus are the main viruses of infection, focusing on the prevention and control of the epidemic in winter and spring, strengthening the immunization of infants and young children, increasing the sample size in monitoring, deepening the research on the genotype of viral diarrhea. The research will have an important role in prevention、control and early warning of diarrhea of viral diarrhea in Nantong City.