幽门螺杆菌根除治疗对幽门螺杆菌阳性的功能性消化不良患者疗效分析

目的 探讨幽门螺杆菌根除治疗对幽门螺杆菌阳性的功能性消化不良（FD）患者疗效。方法 选取2015年1月~2017年1月在本院就诊的幽门螺杆菌阳性的功能性消化不良患者82例，随机分为观察组和对照组。对照组40例采取常规药物（莫沙必利+奥美拉唑）治疗，观察组42例采取四联疗法（兰索拉唑+阿莫西林+克拉霉素+胶体次枸橼酸铋）杀灭幽门螺杆菌治疗，比较两组患者症状改善、临床疗效和不良反应发生情况。结果 两组患者治疗后临床症状积分较治疗前均明显降低，观察组治疗后临床症状积分为（2.71±1.86）分，低于对照组的（8.45±1.92）分，差异有统计学意义（P＜0.05）；观察组不良反应发生率（11.90%）明显低于对照组（22.50%），差异有统计学意义（P＜0.05）；观察组总有效率（92.86%）明显高于对照组（75.00%），差异有统计学意义（P＜0.05）。结论 对于幽门螺杆菌阳性的功能性消化不良患者而言，采取四联疗法杀灭幽门螺杆菌，能更加明显改善其临床症状，提高治疗效果，减少不良反应情况，具有临床推广应用价值。

Efficacy of Helicobacter Pylori Eradication Therapy in Patients with HP Positive Functional Dyspepsia

Abstract:Objective To investigate the efficacy of Helicobacter pylori eradication therapy in the treatment of Helicobacter pylori positive patients with functional dyspepsia(FD).Methods From January 2015 to January 2017,82 patients with Helicobacter pylori positive functional dyspepsia were selected.They were randomly divided into observation group and control group.40 patients in the control group were treated with conventional drugs(mosapride+omeprazole).42 patients in the observation group were treated with tetralogy (lansoprazole+amoxicillin+clarithromycin+colloidal bismuth subcitrate)to kill Helicobacter pylori and make comparison of symptom improvement, clinical efficacy and adverse reactions between the two groups.Results The score of clinical symptom in both groups after treatment was significantly lower than that before treatment,and the clinical symptom score in the observation group was(2.71±1.86)points lower than that in the control group(8.45±1.92),the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(11.90%)was significantly lower than that in the control group(22.50%),the difference was statistically significant(P<0.05).The total effective rate(92.86%)in the observation group was significantly higher than that in the control group(75.00%),the difference was statistically significant(P<0.05).Conclusion For Helicobacter pylori positive functional dyspepsia patients, taking quadruple therapy to kill Helicobacter pylori can more obviously improve its clinical symptoms,improve the therapeutic effect and reduce the adverse reactions, and has clinical application value.