| 心肌纤维化引发心房颤动的研究进展 |
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| 引用本文： | 姜亦瑶1,2,王 凯1,施 超2. 心肌纤维化引发心房颤动的研究进展[J]. 医学信息, 2018, 0(12): 28-30. DOI: 10.3969/j.issn.1006-1959.2018.12.010 |
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| 作者姓名： | 姜亦瑶1 2 王 凯1 施 超2 |
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| 作者单位： | 1.天津市第一中心医院心血管外科，天津 300074；2.蚌埠医学院第一附属医院心脏外科，安徽 蚌埠 233004 |
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| 摘 要： | 以心肌纤维化为代表的心脏重构是心房颤动的发病机制之一，心肌成纤维细胞增殖及异常分泌细胞外基质与心肌纤维化有关。在AngⅡ的作用下，TGF-β1/Smad、PI3K/Akt等信号通路调控CFs增殖。KDM5A在心肌纤维化中的作用已成为研究热点。本文就AngⅡ参与信号通路的最新研究进展进行小结，为理解心肌纤维化在AF进程中的作用提供依据。
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| 关 键 词： | 心房颤动 心肌纤维化 心脏重构 |
Research Progress of Atrial Fibrillation Caused by Myocardial Fibrosis |
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| JIANG Yi-yao1,2,WANG Kai1,SHI Chao2. Research Progress of Atrial Fibrillation Caused by Myocardial Fibrosis[J]. Medical Information, 2018, 0(12): 28-30. DOI: 10.3969/j.issn.1006-1959.2018.12.010 |
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| Authors: | JIANG Yi-yao1 2 WANG Kai1 SHI Chao2 |
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| Affiliation: | 1.Department of Cardiovascular Surgery,Tianjin First Central Hospital,Tianjin 300074,China;2.Department of Cardiac Surgery,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China |
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| Abstract: | Abstract:Cardiac remodeling represented by myocardial fibrosis is one of the pathogenesis of atrial fibrillation.Myocardial fibroblast proliferation and abnormal secretion of extracellular matrix are associated with myocardial fibrosis.Under the action of AngII,TGF-β1/Smad,PI3K/Akt and other signaling pathways regulate CFs proliferation.The role of KDM5A in myocardial fibrosis has become a research hotspot.This article summarizes the latest research progress of AngII involved in the signaling pathway,and provides a basis for understanding the role of myocardial fibrosis in the AF process. |
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| Keywords: | Key words:Atrial fibrillation Myocardial fibrosis Cardiac remodeling |
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