血清胱抑素C及同型半胱氨酸与2型糖尿病视网膜病变的相关性分析

目的 探讨CysC与Hcy与2型糖尿病视网膜病变的相关性。方法 选取我院2017年1月~12月收治的2型糖尿病患者160例，根据眼底照相结果分为糖尿病视网膜病变组（DR组）和糖尿病无视网膜病变组（NDR组），每组80例，同时选取健康受试者80例作为对照组。观察各组患者血糖、血脂、血清CysC及Hcy水平。结果 ①DR组和NDR组SBP、DBP、FBG、2hBG、TG、TC、LDL-C、BUN、SCr、HbA1C、CysC和Hcy水平均高于对照组，差异具有统计学意义（P＜0.05）；DR组和NDR组HDL-C水平低于对照组，差异具有统计学意义（P＜0.05）；DR组SBP、TG、SCr、CysC和Hcy水平高于NDR组，差异具有统计学意义（P＜0.05）。②CysC与病程、TG、SCr、Hcy呈正相关（r=0.428、0.490、0.479、0.215，P＜0.05），与BMI、SBP、LDL-C、FBG无明显相关性。③Logistic多元回归分析显示:TG、SBP、CysC和Hcy为影响2型糖尿病视网膜病变发生的危险因素。结论 高CysC及Hcy水平是发生糖尿病视网膜病变的危险因素，CysC联合Hcy检测对2型糖尿病视网病变的诊治有一定指导意义。

Correlation between Serum Cystatin C and Homocysteine and Type 2 Diabetic Retinopathy

Abstract:Objective To investigate the relationship between CysC and Hcy and type 2 diabetic retinopathy.Methods A total of 160 patients with type 2 diabetes admitted to our hospital from January to December 2017 were enrolled.According to the results of fundus photography,the patients were divided into diabetic retinopathy group(DR group)and diabetic non-retinopathy group(NDR group),80 cases in each group,and 80 healthy subjects were selected as the control group.Blood glucose,blood lipids,serum CysC and Hcy levels were observed in each group.Results ①The levels of SBP,DBP,FBG,2hBG,TG,TC,LDL-C,BUN,SCr,HbA1C,CysC and Hcy in DR group and NDR group were higher than those in the control group,the difference was statistically significant(P<0.05);The HDL-C levels in the DR group and the NDR group were lower than those in the control group,the difference was statistically significant(P<0.05);the levels of SBP,TG,SCr,CysC and Hcy in the DR group were higher than those in the NDR group,the difference was statistically significant(P<0.05).②CysC was positively correlated with disease course,TG,SCr and Hcy(r=0.428,0.490,0.479,0.215,P<0.05),and had no significant correlation with BMI,SBP,LDL-C and FBG.③Logistic multiple regression analysis showed that TG,SBP,CysC and Hcy were risk factors for the development of type 2 diabetic retinopathy.Conclusion High CysC and Hcy levels are risk factors for diabetic retinopathy.CysC combined with Hcy detection has certain guiding significance for the diagnosis and treatment of type 2 diabetic retinopathy.