宁夏某医院患者TB DNA检测分析

目的 探讨宁夏某医院TB DNA感染现状及临床特点。方法 对我院就诊的疑似结核病感染患者1828例进行回顾分析，用实时荧光定量PCR检测血浆TB DNA。结果 TB DNA阳性患者32例，总阳性率为1.75%，男、女性阳性率分别为2.17%和1.17%，差异无统计学意义（P＞0.05）。童年组（0~6岁）阳性率最高为2.86%，与其他年龄组相比，差异无统计学意义（P＞0.05）。春季（3~5月份）TB DNA阳性率最高为3.21%，与其他季节相比，差异有统计学意义（P＜0.05）。2015年~2017年TB DNA阳性率有逐年下降趋势（2.06%、2.00%、1.16%）。TB DNA阳性患者就诊临床科室主要以泌尿外科（6.11%）、呼吸内科（5.26%）、肝胆外科（4.35%）为主。结论 TB DNA检测有助于结核病的早期诊断，为临床防治结核病提供重要依据。

Analysis of TB DNA in Patients in A Hospital in Ningxia

Abstract:Objective To investigate the status and clinical characteristics of TB DNA infection in a hospital in Ningxia.Methods A retrospective analysis of 1828 patients with suspected tuberculosis infection in our hospital was performed,and plasma TB DNA was detected by real-time fluorescent quantitative PCR.Results 32 cases of TB DNA positive patients, the total positive rate was 1.75%, male and female positive rate were 2.17% and 1.17%,respectively,the difference was not statistically significant(P>0.05).The highest positive rate was 2.86% in childhood group(0-6 years old).Compared with other age groups, there was no significant difference(P> 0.05).In spring(March to May),the highest positive rate of TB DNA was 3.21%,compared with other seasons,the difference was statistically significant(P<0.05).The positive rate of TB DNA decreased from 2015 to 2017(2.06%,2.00%,1.16%).The clinical departments of TB DNA-positive patients were mainly urology(6.11%),respiratory medicine(5.26%),and hepatobiliary surgery(4.35%). Conclusion TB DNA detection is helpful for the early diagnosis of tuberculosis and provides an important basis for clinical prevention and treatment of tuberculosis.