氮卓斯汀鼻喷剂联合地氯雷他定治疗变应性鼻炎疗效的Meta分析

目的 应用Meta分析的方法分析氮卓斯汀鼻喷剂联合地氯雷他定治疗变应性鼻炎的疗效。方法 检索的数据库：中文数据库包括CNKI、万方、VIP、CBM等，英文数据库包括PubMed、Embase、Medline、Cochrane等。制定综合检索式，选用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale，NOS）进行质量评估，使用RevMan5.3软件对本次研究的数据进行处理，统计学效应指标选用RR值和95% CI，I²和P值为异质性检验的指标，然后进行敏感性分析、亚组分析、发表偏倚评估。其中发表偏倚评估使用Egger's法，如有必要使用剪补法进一步分析。结果 氮卓斯汀鼻喷剂联合地氯雷他定组与氮卓斯汀鼻喷剂组比较，Z=8.18（P<0.000 01）、RR（95% CI）：1.21（1.16，1.27），差异有统计学意义（P<0.05）。亚组分析显示A组，Z=5.62（P<0.000 01）、RR（95% CI）：1.18（1.12，1.26），差异有统计学意义（P<0.05）。B组Z=3.62（P=0.000 3）、RR（95% CI）：1.19（1.08，1.31），差异有统计学意义（P<0.05）。C组Z=4.91（P<0.000 01）、RR（95% CI）：1.33（1.19，1.50），差异有统计学意义（P<0.05）。敏感性分析示Z=6.27（P<0.000 01）、RR（95% CI）：1.19（1.13，1.26），差异有统计学意义（P<0.05）。结论 氮卓斯汀鼻喷剂联合地氯雷他定比单一使用氮卓斯汀鼻喷剂治疗变应性鼻炎有更好的疗效。

Rapeutic effect of azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis: a system review and Meta-analysis

Objective To analyze therapeutic effect of azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis by Meta analysis.Methods Retrieved database:Chinese database includes CNKI, Wan Fang, VIP, CBM, etc. The English database includes PubMed, Embase, MEDLINE, Cochrane and so on. The quality evaluation was made by the Newcastle Ottawa Scale (NOS). Useing RevMan5.3 software to process data. The statistical effect index was selected by risk ratio (RR) value and 95%CI, I² and P values were selected as indicators of heterogeneity test, and sensitivity analysis, subgroup analysis were carried out. And conduct publication bias assessment. Publication bias was assessed by the Egger's method, if necessary further analysis will be made. Result Compared with azelastine nasal spray combined with desloratadine group and azelastine nasal spray group in the treatment of allergic rhinitis, Z=8.18(P<0.000 01), RR(95% CI):1.21(1.16,1.27) and the difference was statistically significant (P<0.05). Subgroup analysis showed that A group Z=5.62(P<0.000 01) and RR(95% CI):1.18(1.12, 1.26), and the difference was statistically significant (P<0.05). B Group Z=3.62(P=0.000 3) and RR(95% CI):1.19 (1.08, 1.31), the difference was statistically significant (P<0.05). C group Z=4.91(P<0.000 01), RR(95% CI):1.33(1.19, 1.50), the difference was statistically significant (P<0.05). Sensitivity analysis showed that Z=6.27(P<0.000 01), RR(95% CI):1.19(1.13, 1.26), the difference was still statistically significant (P<0.05).Conclusion Azelastine nasal spray combined with desloratadine is better than Azelastine nasal spray in the treatment of allergic rhinitis.