2014-2016年连云港市腹泻人群中诺如病毒流行特征分析

目的 了解2014-2016年连云港诺如病毒在腹泻人群中的感染流行状况,为诺如病毒预防控制提供参考依据。方法 收集2014.1-2016.12连云港地区腹泻粪便样品1 565份,采用实时荧光PCR进行诺如病毒Ⅰ型和Ⅱ型检测,并分析流行状况。结果 2014-2016年,连云港市腹泻人群中诺如病毒总阳性率为8.24%(129/1 565),诺如病毒Ⅰ型(GI)和Ⅱ型(GII)均存在,GI型占6.98%(9/129);GII型占93.02%(120/129)。以GII型为主。各年度、性别、地区腹泻患者中阳性率无差异,0~5岁组、5~65岁组和65~组阳性率有差异;诺如病毒GII型在散居儿童、托幼儿童和学生腹泻人群阳性率9.25%(88/951)高于其他腹泻人群阳性率5.21%(32/614);2014-2016年诺如病毒阳性率依次为6.99%(43/615)、10.06%(49/487)和7.99%(37/463),2014年5月、2015年11月和2016年5月的阳性率高于平均水平。结论 诺如病毒在连云港地区感染稳定存在,有爆发感染的潜在风险,应加强预防控制工作。

Epidemic characteristics of Norovirus in diarrheic population in Lianyungang,2014-2016

Objective To investigate the epidemic characteristics of Norovirus in diarrheic population in Lianyungang from 2014 to 2016,and to provide a scientific basis for developing prevention strategies for norovirus infection. Methods 1 565 faeces samples were collected from a diarrheic population in Lianyungang city between 2014.1-2016.12,and Real-time RT-PCR was used for the detecting of NoVs GI(GI)and NoVs GII(GII).The epidemic situation was analyzed. Results The total positive rate of norovirus among the diarrheic population was 8.24%(129/1 565).Both NoVs GI and NoVs GII were detected,with GI accounting for 6.98%(9/129)and GII accounting for 93.02%(120/129),and NoVs GII was predominant in Lianyungang city.There was no significant difference in years,genders and regions,whereas the positive rate among groups 0~5,5~65 and 65~ was significantly different.It was higher among scattered children、children and students group(9.25%,88/951)than that among the other groups(5.21%,32/614)for NoVs GII positive rate.The positive rates from 2014 to 2016 were 6.99%(43/615),10.06%(49/487)and 7.99%(37/463),with the positive rates(May/2014,Nov/2015,May/2016)especially higher than the average level. Conclusion There is a stable existence of Norovirus infection in Lianyungang,and there is a potential danger of Norovirus outbreak.We should strengthen the surveillance and prevention of Norovirus.