妊娠期同型半胱氨酸和血脂水平对重度子痫前期的预测价值

目的 研究妊娠期同型半胱氨酸和血脂水平对重度子痫前期的预测价值。方法 选取2017年1月~2018年1月在我院治疗后最终分娩的重度子痫前期患者50例为观察组，并选取同期正常妊娠、血压正常、无孕期并发症且足月分娩正常胎儿的50例孕妇为对照组，对比两组孕妇血Hcy、血脂（TC、TG、LDL、HDL、APoB）水平，分析各指标对重度子痫前期的预测价值。结果 观察组产妇Hcy、TG、APoB水平高于对照组，差异有统计学意义（P＜0.05）；叶酸水平低于对照组，差异有统计学意义（P＜0.05）；观察组产妇年龄、体重指数大于对照组，差异有统计学意义（P＜0.05）；Logistic回归分析显示Hcy、年龄是重度子痫前期发生的高危因素。结论 临床联合检测Hcy、血脂等多指标可提高预测重度子痫前期发生风险价值，对临床的诊断和治疗具有重要的临床意义，值得临床重视。

Predictive Value of Homocysteine and Blood Lipid Levels during Pregnancy in Severe Preeclampsia

Abstract:Objective To study the predictive value of homocysteine and blood lipid levels during pregnancy for severe pre-eclampsia. Methods A total of 50 patients with severe pre-eclampsia who were finally delivered after treatment from January 2017 to January 2018 in our hospital were selected as observation group.50 pregnant women with normal pregnancy,normal blood pressure,no pregnancy complications and normal fetuses were selected as the control group,the levels of blood Hcy and blood lipid(TC,TG,LDL, HDL,ApoB)were compared between the two groups,and the predictive value of each index for severe pre-eclampsia was analyzed. Results The levels of Hcy,TG and ApoB in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05);the folate level was lower than the control group,the difference was statistically significant(P<0.05);the maternal age and body mass index of the observation group were larger than the control group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that Hcy and age were risk factors for severe preeclampsia.Conclusion Clinical combined detection of multiple indicators such as Hcy and blood lipid can improve the risk value of predicting severe preeclampsia,and has important clinical significance for clinical diagnosis and treatment.It is worthy of clinical attention.