唑来膦酸注射液联合金天格胶囊治疗 绝经后骨质疏松症疗效分析

目的 分析唑来膦酸注射液与金天格胶囊联合治疗绝经后骨质疏松症的效果及VAS评分。方法 选取2016年6月~2018年6月本院68例绝经后骨质疏松患者的临床资料，按照数字随机法分为对照组和研究组，各34例。对照组给予唑来膦酸注射液治疗，研究组给予唑来膦酸注射液与金天格胶囊联合治疗，比较两组的实验室相关指标、骨密度及VAS评分。结果 研究组骨密度腰椎（0.92±0.15）g/cm2、股骨颈（0.85±0.17）g/cm2、股骨大转子（0.91±0.13）g/cm2、Ward's三角区（0.81±0.12）g/cm2，高于对照组（0.72±0.11）g/cm2、（0.62±0.08）g/cm2、（0.68±0.11）g/cm2、（0.61±0.08）g/cm2，差异有统计学意义（P＜0.05）；骨钙素（10.28±1.27）ng/ml、骨特异性碱性磷酸酶（20.12±3.06）U/L，异有统计学意义（P＜0.05）；VAS评分（1.66±0.12）分，低于对照组（3.88±1.06）分，差异有统计学意义（P＜0.05）。结论 唑来膦酸注射液联合金天格胶囊治疗绝经后骨质疏松症的临床效果显著，有利于改善患者的骨密度和骨代谢指标，减轻疼痛。

Therapeutic Effect of Zoledronic Acid Injection Combined with Jintiange Capsule on Postmenopausal Osteoporosis

Abstract:Objective To analyze the effect of zoledronic acid injection combined with Jintiange capsule on postmenopausal osteoporosis and VAS score.Methods The clinical data of 68 postmenopausal osteoporosis patients from June 2016 to June 2018 were selected and divided into control group and study group according to the numerical random method,34 cases each.The control group was treated with zoledronic acid injection.The study group was given zoledronic acid injection combined with Jintiange capsule. The laboratory-related index, bone mineral density and VAS score were compared between the two groups.Results The study group bone mineral density lumbar vertebrae(0.92±0.15)g/cm2,femoral neck(0.85±0.17)g/cm2,femur greater trochanter(0.91±0.13)g/cm2,ward's triangle(0.81±0.12)g/cm2,higher than the control group(0.72±0.11)g/cm2,(0.62±0.08)g/cm2,(0.68±0.11)g/cm2,(0.61±0.08)g/cm2,the difference was statistically significant(P<0.05);Osteocalcin (10.28±1.27)ng/ml,bone-specific alkaline phosphatase(20.12±3.06)U/L,statistically significant(P<0.05);VAS score(1.66±0.12),lower than the control group(3.88±1.06)points,the difference was statistically significant(P<0.05).Conclusion The clinical effect of zoledronic acid injection combined with Jintiange capsule in the treatment of postmenopausal osteoporosis is significant,which is beneficial to improve bone mineral density and bone metabolism and reduce pain.