| 炎症性肠病合并艰难梭菌感染的研究进展 |
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| 引用本文： | 李玥,钱家鸣.炎症性肠病合并艰难梭菌感染的研究进展[J].临床荟萃,2018,33(5):394. |
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| 作者姓名： | 李玥 钱家鸣 |
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| 作者单位： | 中国医学科学院&北京协和医学院北京协和医院消化科，北京100730 |
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| 基金项目： | 国医学科学院医学与健康科技创新工程项目（2017 I2M 3 017）：协同创新团队“人体微生物组平台建设与应用研究”；北京协和医学院青年教师培养项目（2015zlgc0706）；2010国家临床重点专科项目 |
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| 摘 要： | 艰难梭菌感染（Clostridium difficile infection，CDI）在炎症性肠病（inflammatory bowel disease，IBD）患者中的发生率不断上升。CDI明显增加IBD患者预后不良如死亡和结肠切除手术率。有关IBD合并CDI的相关研究显示，肠道微生态、免疫和遗传因素共同决定了IBD发生CDI的风险。进一步的机制研究将有助于CDI的预防和治疗。
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| 关 键 词： | 炎性肠疾病 梭菌感染 肠道微生态 遗传易感性 |
Study advances of inflammatory bowel disease complicated with Clostridium difficile infection |
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| Li Yue,Qian Jiaming.Study advances of inflammatory bowel disease complicated with Clostridium difficile infection[J].Clinical Focus,2018,33(5):394. |
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| Authors: | Li Yue Qian Jiaming |
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| Institution: | Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of ;
Medical Science & Peking Union Medical College, Beijing 100730, China |
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| Abstract: | Studies have demonstrated an increasing incidence of Clostridium difficile infection (CDI) in patients with inflammatory bowel disease (IBD). CDI can both precipitate and worsen flares of IBD, contributing to emergent colectomies and mortality. Host microbiome, immune response and genetics jointly decide whether patients with IBD will suffer from CDI. Further studies may help define pathogenesis of CDI as well as identify high risk subgroups that may benefit from prophylactic intervention. |
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| Keywords: | inflammatory bowel disease Clostridium infections intestinal microbiome genetics
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