|
|||||
|
|
| 阻塞性睡眠呼吸暂停致心肌损伤的临床和基础研究进展 | |
| 引用本文： | 李泽萱,王晓,赵冠棋,范婧尧,郝问,周生辉,郭芮丰,李奥博,石涵,聂绍平,魏永祥. 阻塞性睡眠呼吸暂停致心肌损伤的临床和基础研究进展[J]. 中国全科医学, 2018, 21(33): 4067-4071. DOI: 10.12114/j.issn.1007-9572.2018.00.262 |
| 作者姓名： | 李泽萱 王晓 赵冠棋 范婧尧 郝问 周生辉 郭芮丰 李奥博 石涵 聂绍平 魏永祥 |
| 作者单位： | 1.100029北京市，首都医科大学附属北京安贞医院急诊危重症中心 2.100029北京市，首都医科大学附属北京安贞医院耳鼻咽喉头颈外科中心 *通信作者：聂绍平，教授，主任医师；E-mail：spnie@ccmu.edu.cn |
| 基金项目： | 基金项目：国家自然科学基金青年项目（81600209）；国家国际科技合作专项（2015DFA30160）；北京市医管局重点医学发展计划（ZYLX201710）；北京市医管局科研培育计划（PX2016048）；北京市委组织部“北京市优秀人才”（2016000021469G194）；北京市医管局“青苗”计划（QML20160605） |
| 摘 要： | 阻塞性睡眠呼吸暂停（OSA）是指睡眠过程中上气道完全或部分阻塞导致反复呼吸暂停和/或呼吸浅慢，进而导致微觉醒、间断低氧及白天过度嗜睡。OSA诱导的慢性间歇性低氧会引起交感神经兴奋、内皮功能障碍、全身炎症、氧化应激和代谢紊乱，均可诱发或加重心肌损伤。多项研究证实，OSA可以引起心肌损伤标志物升高、促进左心室重塑和功能下降，是心血管疾病发病和不良预后的独立预测因素。目前，OSA引起心肌损伤发生、发展的病理生理机制及其临床意义还有待深入研究。本文对OSA与心肌损伤关联的临床和基础研究进展进行综述。 |
| 关 键 词： | 睡眠呼吸暂停 阻塞性 心肌疾病 心脏损伤 间歇性低氧 |
Progresses in Clinical and Basic Research of Myocardial Injury Caused by Obstructive Sleep Apnea |
|
| LI Zexuan,WANG Xiao,ZHAO Guanqi,FAN Jingyao,HAO Wen,ZHOU Shenghui,GUO Ruifeng,LI Aobo,SHI Han,NIE Shaoping,WEI Yongxiang. Progresses in Clinical and Basic Research of Myocardial Injury Caused by Obstructive Sleep Apnea[J]. Chinese General Practice, 2018, 21(33): 4067-4071. DOI: 10.12114/j.issn.1007-9572.2018.00.262 | |
| Authors: | LI Zexuan WANG Xiao ZHAO Guanqi FAN Jingyao HAO Wen ZHOU Shenghui GUO Ruifeng LI Aobo SHI Han NIE Shaoping WEI Yongxiang |
| Affiliation: | 1.Emergency & Critical Care Center，Beijing Anzhen Hospital，Capital Medical University，Beijing 100029，China 2.Otolaryngology-Head and Neck Surgery Center，Beijing Anzhen Hospital，Capital Medical University，Beijing 100029，China *Corresponding author：NIE Shaoping，Professor，Chief physician；E-mail：spnie@ccmu.edu.cn |
| Abstract: | Obstructive sleep apnea（OSA） refers to the complete or partial obstruction of the upper airway during sleep，resulting in repeated apnea and/or hypopnea，in turn leading to microarousal，intermittent hypoxia and excessive daytime sleepiness.OSA-induced chronic intermittent hypoxia，can cause sympathetic nervous excitement，endothelial dysfunction，systemic inflammation，oxidative stress and metabolic disorders，can induce or aggravate myocardial injury.Many studies have confirmed that OSA can cause myocardial injury markers increasing，and promote left ventricular remodeling and decreased cardiac function，and is an independent predictor of cardiovascular morbidity and poor prognosis.At present，the pathophysiological mechanism and development of myocardial injury caused by OSA remains to be further studied.The objective of this review was to discuss the clinical and basic research related to OSA and myocardial injury. |
| Keywords: | Sleep apnea obstructive；Cardiomyopathies；Heart injuries；Intermittent hypoxia |
| 点击此处可从《中国全科医学》浏览原始摘要信息 | |
| 点击此处可从《中国全科医学》下载全文 | |