桂枝茯苓汤辨证加味对晚期宫颈癌化学药物治疗患者的增效减毒作用

目的 探讨桂枝茯苓汤辨证加味对晚期宫颈癌化学药物治疗（以下简称化疗）患者的增效减毒作用。方法 选取2015年2月至2017年3月收治的晚期宫颈癌患者84例，利用数字表法随机将其分为单一组及联合组，各42例。单一组给予紫杉醇+顺铂（taxinol plus platinum，TP）化疗方案治疗，联合组在单一组基础上给予桂枝茯苓汤辨证加味治疗。对比两组患者临床疗效，且均于治疗前后抽取外周静脉血，检测并比较治疗前后血清免疫球蛋白（IgG、IgA、IgM）和T淋巴细胞亚群（CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺）的变化，并对比两组患者不良反应发生情况。结果 两组临床疗效等级分布比较差异有统计学意义（P<0.05），且联合组临床获益率明显高于单一组（P<0.05）；单一组治疗后血清IgG、IgA、IgM、CD3⁺、CD4⁺、CD4⁺/CD8⁺均明显低于治疗前（P<0.05），CD8⁺明显高于治疗前（P<0.05），但联合组治疗前后血清IgG、IgA、IgM、CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺均差异无统计学意义（P>0.05），且联合组治疗后血清IgG、IgA、IgM、CD3⁺、CD4⁺、CD4⁺/CD8⁺均明显高于单一组（P<0.05），CD8⁺明显低于单一组（P<0.05）；联合组骨髓抑制、直肠刺激反应、皮肤反应及膀胱刺激反应发生率均明显低于单一组（P<0.05）。结论 桂枝茯苓汤辨证加味应用于晚期宫颈癌化疗患者，可显著提高临床疗效，维持机体免疫功能稳定，并减少不良反应。

Effect of synergism and attenuation of Guizhi Fuling decoction in patients with advanced cervical cancer treated with chemotherapy

Objective To investigate the effect of synergism and attenuation of Guizhi Fuling decoction in patients with advanced cervical cancer treated with chemotherapy. Methods Eighty-four patients with advanced cervical cancer were admitted from February 2015 to March 2017, who were divided into single group and combination group by random digital table method, and there were 42 cases in each group. The single group was treated with taxinol plus platinum (TP) chemotherapy, while the combination group was treated with Guizhi Fuling decoction on the basis of the single group. The clinical effect was compared, and the peripheral blood samples of patients of the two groups before and after treatment were collected, then the levels of the serum immunoglobulin (IgG, IgA, IgM) and T lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺) of the two groups were detected and compared, as well as the toxic and side reactions of patients. Results The grade distribution of the clinical effect between the two groups had a significant difference (P<0.05), and the clinical benefit rate (CBR) of the combination group was significantly higher than that of the single group (P<0.05). The levels of serum IgG, IgA, IgM, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ of the single group after treatment were significantly lower than those before treatment (P<0.05), and CD8⁺ of the single group after treatment was significantly higher than that before treatment (P<0.05), but the levels of serum IgG, IgA, IgM, CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ of the combination group before treatment and after treatment showed no significant differences (P>0.05), and the levels of serum IgG, IgA, IgM, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ of the combination group after treatment were significantly higher than those of the single group (P<0.05), but CD8+ was significantly lower than that of the single group (P<0.05). The incidence rates of bone marrow suppression, rectal irritation, skin reaction and bladder irritation of the combination group were significantly lower than those of the single group (P<0.05). Conclusion Guizhi Fuling decoction in the treatment of advanced cervical cancer patients with chemotherapy can significantly improve the clinical effect, maintain the stability of the body's immune function and reduce the incidence of toxic and side reactions.